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ATG7(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism.
Ostacolo K, López García de Lomana A, Larat C, Hjaltalin V, Holm KY, Hlynsdóttir SS, Soucheray M, Sooman L, Rolfsson O, Krogan NJ, Steingrimsson E, Swaney DL, Ogmundsdottir MH. Ostacolo K, et al. Among authors: steingrimsson e. Traffic. 2024 Apr;25(4):e12933. doi: 10.1111/tra.12933. Traffic. 2024. PMID: 38600522
Novel mechanisms of MITF regulation and melanoma predisposition identified in a mouse suppressor screen.
Vu HN, Valdimarsson MM, Sigurbjörnsdóttir S, Bergsteinsdóttir K, Debbache J, Bismuth K, Swing DA, Hallsson JH, Larue L, Arnheiter H, Copeland NG, Jenkins NA, Heidarsson PO, Steingrímsson E. Vu HN, et al. Among authors: steingrimsson e. bioRxiv [Preprint]. 2023 Aug 4:2023.08.04.551952. doi: 10.1101/2023.08.04.551952. bioRxiv. 2023. PMID: 37786677 Free PMC article. Preprint.
Acetylation reprograms MITF target selectivity and residence time.
Louphrasitthiphol P, Loffreda A, Pogenberg V, Picaud S, Schepsky A, Friedrichsen H, Zeng Z, Lashgari A, Thomas B, Patton EE, Wilmanns M, Filippakopoulos P, Lambert JP, Steingrímsson E, Mazza D, Goding CR. Louphrasitthiphol P, et al. Among authors: steingrimsson e. Nat Commun. 2023 Sep 28;14(1):6051. doi: 10.1038/s41467-023-41793-7. Nat Commun. 2023. PMID: 37770430 Free PMC article.
Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62.
Greer SU, Chen J, Ogmundsdottir MH, Ayala C, Lau BT, Delacruz RGC, Sandoval IT, Kristjansdottir S, Jones DA, Haslem DS, Romero R, Fulde G, Bell JM, Jonasson JG, Steingrimsson E, Ji HP, Nadauld LD. Greer SU, et al. Among authors: steingrimsson e. Sci Rep. 2022 Jun 20;12(1):10333. doi: 10.1038/s41598-022-13569-4. Sci Rep. 2022. PMID: 35725745 Free PMC article.
Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms.
Zhang T, Choi J, Dilshat R, Einarsdóttir BÓ, Kovacs MA, Xu M, Malasky M, Chowdhury S, Jones K, Bishop DT, Goldstein AM, Iles MM, Landi MT, Law MH, Shi J, Steingrímsson E, Brown KM. Zhang T, et al. Among authors: steingrimsson e. Am J Hum Genet. 2021 Sep 2;108(9):1631-1646. doi: 10.1016/j.ajhg.2021.06.018. Epub 2021 Jul 21. Am J Hum Genet. 2021. PMID: 34293285 Free PMC article.
BRN2 is a non-canonical melanoma tumor-suppressor.
Hamm M, Sohier P, Petit V, Raymond JH, Delmas V, Le Coz M, Gesbert F, Kenny C, Aktary Z, Pouteaux M, Rambow F, Sarasin A, Charoenchon N, Bellacosa A, Sanchez-Del-Campo L, Mosteo L, Lauss M, Meijer D, Steingrimsson E, Jönsson GB, Cornell RA, Davidson I, Goding CR, Larue L. Hamm M, et al. Among authors: steingrimsson e. Nat Commun. 2021 Jun 17;12(1):3707. doi: 10.1038/s41467-021-23973-5. Nat Commun. 2021. PMID: 34140478 Free PMC article.
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