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Targeting transcription factor STAT3 for cancer prevention and therapy.
Chai EZ, Shanmugam MK, Arfuso F, Dharmarajan A, Wang C, Kumar AP, Samy RP, Lim LH, Wang L, Goh BC, Ahn KS, Hui KM, Sethi G. Chai EZ, et al. Among authors: sethi g. Pharmacol Ther. 2016 Jun;162:86-97. doi: 10.1016/j.pharmthera.2015.10.004. Epub 2016 Feb 12. Pharmacol Ther. 2016. PMID: 26478441 Review.
Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model.
Zhang J, Ahn KS, Kim C, Shanmugam MK, Siveen KS, Arfuso F, Samym RP, Deivasigamanim A, Lim LH, Wang L, Goh BC, Kumar AP, Hui KM, Sethi G. Zhang J, et al. Among authors: sethi g. Antioxid Redox Signal. 2016 Apr 10;24(11):575-89. doi: 10.1089/ars.2015.6418. Epub 2016 Jan 26. Antioxid Redox Signal. 2016. PMID: 26649526
A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma.
Dai X, Wang L, Deivasigamni A, Looi CY, Karthikeyan C, Trivedi P, Chinnathambi A, Alharbi SA, Arfuso F, Dharmarajan A, Goh BC, Hui KM, Kumar AP, Mustafa MR, Sethi G. Dai X, et al. Among authors: sethi g. Oncotarget. 2017 Feb 21;8(8):12831-12842. doi: 10.18632/oncotarget.14606. Oncotarget. 2017. PMID: 28086233 Free PMC article.
Therapeutic potential of gambogic acid, a caged xanthone, to target cancer.
Banik K, Harsha C, Bordoloi D, Lalduhsaki Sailo B, Sethi G, Leong HC, Arfuso F, Mishra S, Wang L, Kumar AP, Kunnumakkara AB. Banik K, et al. Among authors: sethi g. Cancer Lett. 2018 Mar 1;416:75-86. doi: 10.1016/j.canlet.2017.12.014. Epub 2017 Dec 13. Cancer Lett. 2018. PMID: 29246645 Review.
Pan-HDAC inhibition by panobinostat mediates chemosensitization to carboplatin in non-small cell lung cancer via attenuation of EGFR signaling.
Wang L, Syn NL, Subhash VV, Any Y, Thuya WL, Cheow ESH, Kong L, Yu F, Peethala PC, Wong AL, Laljibhai HJ, Chinnathambi A, Ong PS, Ho PC, Sethi G, Yong WP, Goh BC. Wang L, et al. Among authors: sethi g. Cancer Lett. 2018 Mar 28;417:152-160. doi: 10.1016/j.canlet.2017.12.030. Epub 2018 Jan 4. Cancer Lett. 2018. PMID: 29306016
902 results