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Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Ducker GS, et al. Among authors: rabinowitz jd. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9. Proc Natl Acad Sci U S A. 2017. PMID: 29073064 Free PMC article.
Mitochondrial translation requires folate-dependent tRNA methylation.
Morscher RJ, Ducker GS, Li SH, Mayer JA, Gitai Z, Sperl W, Rabinowitz JD. Morscher RJ, et al. Among authors: rabinowitz jd. Nature. 2018 Feb 1;554(7690):128-132. doi: 10.1038/nature25460. Epub 2018 Jan 24. Nature. 2018. PMID: 29364879 Free PMC article.
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.
Ghergurovich JM, García-Cañaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD. Ghergurovich JM, et al. Among authors: rabinowitz jd. Nat Chem Biol. 2020 Jul;16(7):731-739. doi: 10.1038/s41589-020-0533-x. Epub 2020 May 11. Nat Chem Biol. 2020. PMID: 32393898 Free PMC article.
A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.
Martin JK 2nd, Sheehan JP, Bratton BP, Moore GM, Mateus A, Li SH, Kim H, Rabinowitz JD, Typas A, Savitski MM, Wilson MZ, Gitai Z. Martin JK 2nd, et al. Among authors: rabinowitz jd. Cell. 2020 Jun 25;181(7):1518-1532.e14. doi: 10.1016/j.cell.2020.05.005. Epub 2020 Jun 3. Cell. 2020. PMID: 32497502 Free PMC article.
The Source of Glycolytic Intermediates in Mammalian Tissues.
TeSlaa T, Bartman CR, Jankowski CSR, Zhang Z, Xu X, Xing X, Wang L, Lu W, Hui S, Rabinowitz JD. TeSlaa T, et al. Among authors: rabinowitz jd. Cell Metab. 2021 Feb 2;33(2):367-378.e5. doi: 10.1016/j.cmet.2020.12.020. Epub 2021 Jan 19. Cell Metab. 2021. PMID: 33472024 Free PMC article.
Monitoring mammalian mitochondrial translation with MitoRiboSeq.
Li SH, Nofal M, Parsons LR, Rabinowitz JD, Gitai Z. Li SH, et al. Among authors: rabinowitz jd. Nat Protoc. 2021 Jun;16(6):2802-2825. doi: 10.1038/s41596-021-00517-1. Epub 2021 May 5. Nat Protoc. 2021. PMID: 33953394 Free PMC article.
296 results