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A structural view of PA2G4 isoforms with opposing functions in cancer.
Stevenson BW, Gorman MA, Koach J, Cheung BB, Marshall GM, Parker MW, Holien JK. Stevenson BW, et al. J Biol Chem. 2020 Nov 20;295(47):16100-16112. doi: 10.1074/jbc.REV120.014293. Epub 2020 Sep 20. J Biol Chem. 2020. PMID: 32952126 Free PMC article. Review.
Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.
Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM. Koach J, et al. Among authors: stevenson bw. Cancer Res. 2019 Nov 1;79(21):5652-5667. doi: 10.1158/0008-5472.CAN-19-1112. Epub 2019 Sep 9. Cancer Res. 2019. PMID: 31501192
Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface.
Massudi H, Luo JS, Holien JK, Gadde S, Krishan S, Herath M, Koach J, Stevenson BW, Gorman MA, Venkat P, Mayoh C, Luo XQ, Parker MW, Cheung BB, Marshall GM. Massudi H, et al. Among authors: stevenson bw. Cancers (Basel). 2023 Mar 17;15(6):1822. doi: 10.3390/cancers15061822. Cancers (Basel). 2023. PMID: 36980710 Free PMC article.
ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.
Maxwell MB, Hom-Tedla MS, Yi J, Li S, Rivera SA, Yu J, Burns MJ, McRae HM, Stevenson BT, Coakley KE, Ho J, Gastelum KB, Bell JC, Jones AC, Eskander RN, Dykhuizen EC, Shadel GS, Kaech SM, Hargreaves DC. Maxwell MB, et al. Among authors: stevenson bt. Cell. 2024 May 9:S0092-8674(24)00451-3. doi: 10.1016/j.cell.2024.04.025. Online ahead of print. Cell. 2024. PMID: 38754421
604 results