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Mechano-sensitivity of β2-adrenoceptors enhances constitutive activation of cAMP generation that is inhibited by inverse agonists.
Commun Biol. 2024 Apr 5;7(1):417. doi: 10.1038/s42003-024-06128-2.
Commun Biol. 2024.
PMID: 38580813
Free PMC article.
Kinetic analysis of endogenous β2 -adrenoceptor-mediated cAMP GloSensor™ responses in HEK293 cells.
Cullum SA, Veprintsev DB, Hill SJ.
Cullum SA, et al.
Br J Pharmacol. 2023 May;180(10):1304-1315. doi: 10.1111/bph.16008. Epub 2023 Jan 6.
Br J Pharmacol. 2023.
PMID: 36495270
Free PMC article.
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ThermoBRET: A Ligand-Engagement Nanoscale Thermostability Assay Applied to GPCRs.
Hoare BL, Tippett DN, Kaur A, Cullum SA, Miljuš T, Koers EJ, Harwood CR, Dijon N, Holliday ND, Sykes DA, Veprintsev DB.
Hoare BL, et al. Among authors: cullum sa.
Chembiochem. 2024 Jan 15;25(2):e202300459. doi: 10.1002/cbic.202300459. Epub 2023 Nov 28.
Chembiochem. 2024.
PMID: 37872746
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Combined docking and machine learning identify key molecular determinants of ligand pharmacological activity on β2 adrenoceptor.
Jiménez-Rosés M, Morgan BA, Jimenez Sigstad M, Tran TDZ, Srivastava R, Bunsuz A, Borrega-Román L, Hompluem P, Cullum SA, Harwood CR, Koers EJ, Sykes DA, Styles IB, Veprintsev DB.
Jiménez-Rosés M, et al. Among authors: cullum sa.
Pharmacol Res Perspect. 2022 Oct;10(5):e00994. doi: 10.1002/prp2.994.
Pharmacol Res Perspect. 2022.
PMID: 36029004
Free PMC article.
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Structural Basis of the Negative Allosteric Modulation of 5-BDBD at Human P2X4 Receptors.
Bidula S, Nadzirin IB, Cominetti M, Hickey H, Cullum SA, Searcey M, Schmid R, Fountain SJ.
Bidula S, et al. Among authors: cullum sa.
Mol Pharmacol. 2022 Jan;101(1):33-44. doi: 10.1124/molpharm.121.000402. Epub 2021 Oct 30.
Mol Pharmacol. 2022.
PMID: 34718224
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