Churchman LS - Search Results

1

Post-transcriptional splicing can occur in a slow-moving zone around the gene.

Coté A, O'Farrell A, Dardani I, Dunagin M, Coté C, Wan Y, Bayatpour S, Drexler HL, Alexander KA, Chen F, Wassie AT, Patel R, Pham K, Boyden ES, Berger S, Phillips-Cremins J, Churchman LS, Raj A. Coté A, et al. Among authors: churchman ls. Elife. 2024 Apr 5;12:RP91357. doi: 10.7554/eLife.91357. Elife. 2024. PMID: 38577979 Free PMC article.

2

Single mammalian cells compensate for differences in cellular volume and DNA copy number through independent global transcriptional mechanisms.

Padovan-Merhar O, Nair GP, Biaesch AG, Mayer A, Scarfone S, Foley SW, Wu AR, Churchman LS, Singh A, Raj A. Padovan-Merhar O, et al. Among authors: churchman ls. Mol Cell. 2015 Apr 16;58(2):339-52. doi: 10.1016/j.molcel.2015.03.005. Epub 2015 Apr 9. Mol Cell. 2015. PMID: 25866248 Free PMC article.

3

Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores.

Drexler HL, Choquet K, Churchman LS. Drexler HL, et al. Among authors: churchman ls. Mol Cell. 2020 Mar 5;77(5):985-998.e8. doi: 10.1016/j.molcel.2019.11.017. Epub 2019 Dec 12. Mol Cell. 2020. PMID: 31839405 Free PMC article.

4

Revealing nascent RNA processing dynamics with nano-COP.

Drexler HL, Choquet K, Merens HE, Tang PS, Simpson JT, Churchman LS. Drexler HL, et al. Among authors: churchman ls. Nat Protoc. 2021 Mar;16(3):1343-1375. doi: 10.1038/s41596-020-00469-y. Epub 2021 Jan 29. Nat Protoc. 2021. PMID: 33514943 Free PMC article.

5

Transcription elongation is finely tuned by dozens of regulatory factors.

Couvillion M, Harlen KM, Lachance KC, Trotta KL, Smith E, Brion C, Smalec BM, Churchman LS. Couvillion M, et al. Among authors: churchman ls. Elife. 2022 May 16;11:e78944. doi: 10.7554/eLife.78944. Elife. 2022. PMID: 35575476 Free PMC article.

6

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness.

Tye BW, Commins N, Ryazanova LV, Wühr M, Springer M, Pincus D, Churchman LS. Tye BW, et al. Among authors: churchman ls. Elife. 2019 Mar 7;8:e43002. doi: 10.7554/eLife.43002. Elife. 2019. PMID: 30843788 Free PMC article.

7

Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic transcripts.

Choquet K, Baxter-Koenigs AR, Dülk SL, Smalec BM, Rouskin S, Churchman LS. Choquet K, et al. Among authors: churchman ls. Nat Struct Mol Biol. 2023 Aug;30(8):1064-1076. doi: 10.1038/s41594-023-01035-2. Epub 2023 Jul 13. Nat Struct Mol Biol. 2023. PMID: 37443198

8

Genome-wide profiling of RNA polymerase transcription at nucleotide resolution in human cells with native elongating transcript sequencing.

Mayer A, Churchman LS. Mayer A, et al. Among authors: churchman ls. Nat Protoc. 2016 Apr;11(4):813-33. doi: 10.1038/nprot.2016.047. Epub 2016 Mar 24. Nat Protoc. 2016. PMID: 27010758 Free PMC article.

9

Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis.

Boswell SA, Snavely A, Landry HM, Churchman LS, Gray JM, Springer M. Boswell SA, et al. Among authors: churchman ls. Nat Chem Biol. 2017 May;13(5):501-507. doi: 10.1038/nchembio.2317. Epub 2017 Mar 6. Nat Chem Biol. 2017. PMID: 28263964 Free PMC article.

10

Native elongating transcript sequencing (NET-seq).

Churchman LS, Weissman JS. Churchman LS, et al. Curr Protoc Mol Biol. 2012 Apr;Chapter 4:Unit 4.14.1-17. doi: 10.1002/0471142727.mb0414s98. Curr Protoc Mol Biol. 2012. PMID: 22470065

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