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Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.
Fukushima T, Arai T, Ariga-Nedachi M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Asano T, Hakuno F, Takahashi S. Fukushima T, et al. Biochem Biophys Res Commun. 2011 Jan 21;404(3):767-73. doi: 10.1016/j.bbrc.2010.12.045. Epub 2010 Dec 17. Biochem Biophys Res Commun. 2011. PMID: 21168390
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S. Yoshihara H, et al. Biochem Biophys Res Commun. 2012 Jun 22;423(1):122-7. doi: 10.1016/j.bbrc.2012.05.093. Epub 2012 May 23. Biochem Biophys Res Commun. 2012. PMID: 22634009
USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination.
Fukushima T, Yoshihara H, Furuta H, Hakuno F, Iemura SI, Natsume T, Nakatsu Y, Kamata H, Asano T, Komada M, Takahashi SI. Fukushima T, et al. Among authors: takahashi si. Biochem Biophys Res Commun. 2017 Mar 11;484(3):522-528. doi: 10.1016/j.bbrc.2017.01.101. Epub 2017 Jan 23. Biochem Biophys Res Commun. 2017. PMID: 28126338
IGF1 receptor signaling pathways.
Hakuno F, Takahashi SI. Hakuno F, et al. Among authors: takahashi si. J Mol Endocrinol. 2018 Jul;61(1):T69-T86. doi: 10.1530/JME-17-0311. Epub 2018 Mar 13. J Mol Endocrinol. 2018. PMID: 29535161 Review.
144 results