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Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical Matter─Compounds with Novel Mechanisms from High-Throughput Screening Profiles.
Thomas JR, Shelton C 4th, Murphy J, Brittain S, Bray MA, Aspesi P, Concannon J, King FJ, Ihry RJ, Ho DJ, Henault M, Hadjikyriacou A, Neri M, Sigoillot FD, Pham HT, Shum M, Barys L, Jones MD, Martin EJ, Blechschmidt A, Rieffel S, Troxler TJ, Mapa FA, Jenkins JL, Jain RK, Kutchukian PS, Schirle M, Renner S. Thomas JR, et al. Among authors: kutchukian ps. ACS Chem Biol. 2024 Apr 19;19(4):938-952. doi: 10.1021/acschembio.3c00737. Epub 2024 Apr 2. ACS Chem Biol. 2024. PMID: 38565185 Free PMC article.
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Bukhtiyarova M, Cook EM, Hancock PJ, Hruza AW, Shaw AW, Adam GC, Barnard RJO, McKenna PM, Holloway MK, Bell IM, Carroll S, Cornella-Taracido I, Cox CD, Kutchukian PS, Powell DA, Strickland C, Trotter BW, Tudor M, Wolkenberg S, Li J, Tellers DM. Bukhtiyarova M, et al. Among authors: kutchukian ps. ACS Med Chem Lett. 2020 Dec 23;12(1):99-106. doi: 10.1021/acsmedchemlett.0c00551. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488970 Free PMC article.
Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis.
Zhang J, Muise ES, Han S, Kutchukian PS, Costet P, Zhu Y, Kan Y, Zhou H, Shah V, Huang Y, Saigal A, Akiyama TE, Shen XL, Cai TQ, Shah K, Carballo-Jane E, Zycband E, Yi L, Tian Y, Chen Y, Imbriglio J, Smith E, Devito K, Conway J, Ma LJ, Hoek M, Sebhat IK, Peier AM, Talukdar S, McLaren DG, Previs SF, Jensen KK, Pinto S. Zhang J, et al. Among authors: kutchukian ps. Cell Rep Med. 2020 Jul 21;1(4):100056. doi: 10.1016/j.xcrm.2020.100056. eCollection 2020 Jul 21. Cell Rep Med. 2020. PMID: 33205063 Free PMC article.
CHEMGENIE: integration of chemogenomics data for applications in chemical biology.
Kutchukian PS, Chang C, Fox SJ, Cook E, Barnard R, Tellers D, Wang H, Pertusi D, Glick M, Sheridan RP, Wallace IM, Wassermann AM. Kutchukian PS, et al. Drug Discov Today. 2018 Jan;23(1):151-160. doi: 10.1016/j.drudis.2017.09.004. Epub 2017 Sep 14. Drug Discov Today. 2018. PMID: 28917822 Review.
Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.
Santa Maria JP Jr, Park Y, Yang L, Murgolo N, Altman MD, Zuck P, Adam G, Chamberlin C, Saradjian P, Dandliker P, Boshoff HIM, Barry CE 3rd, Garlisi C, Olsen DB, Young K, Glick M, Nickbarg E, Kutchukian PS. Santa Maria JP Jr, et al. Among authors: kutchukian ps. ACS Chem Biol. 2017 Sep 15;12(9):2448-2456. doi: 10.1021/acschembio.7b00468. Epub 2017 Aug 29. ACS Chem Biol. 2017. PMID: 28806050 Free PMC article.
Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.
Pertusi DA, O'Donnell G, Homsher MF, Solly K, Patel A, Stahler SL, Riley D, Finley MF, Finger EN, Adam GC, Meng J, Bell DJ, Zuck PD, Hudak EM, Weber MJ, Nothstein JE, Locco L, Quinn C, Amoss A, Squadroni B, Hartnett M, Heo MR, White T, May SA, Boots E, Roberts K, Cocchiarella P, Wolicki A, Kreamer A, Kutchukian PS, Wassermann AM, Uebele VN, Glick M, Rusinko A 3rd, Culberson JC. Pertusi DA, et al. Among authors: kutchukian ps. SLAS Discov. 2017 Sep;22(8):995-1006. doi: 10.1177/2472555217706058. Epub 2017 Apr 20. SLAS Discov. 2017. PMID: 28426940 Free article.
Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.
Kutchukian PS, Warren L, Magliaro BC, Amoss A, Cassaday JA, O'Donnell G, Squadroni B, Zuck P, Pascarella D, Culberson JC, Cooke AJ, Hurzy D, Schlegel KS, Thomson F, Johnson EN, Uebele VN, Hermes JD, Parmentier-Batteur S, Finley M. Kutchukian PS, et al. ACS Chem Biol. 2017 Feb 17;12(2):519-527. doi: 10.1021/acschembio.6b00913. Epub 2017 Jan 6. ACS Chem Biol. 2017. PMID: 28032990 Free article.
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.
Greshock TJ, Moore KP, McClain RT, Bellomo A, Chung CK, Dreher SD, Kutchukian PS, Peng Z, Davies IW, Vachal P, Ellwart M, Manolikakes SM, Knochel P, Nantermet PG. Greshock TJ, et al. Among authors: kutchukian ps. Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13714-13718. doi: 10.1002/anie.201604652. Epub 2016 Sep 30. Angew Chem Int Ed Engl. 2016. PMID: 27690172
25 results