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Induction of complementary immunogenic necroptosis and apoptosis cell death pathways inhibits cancer metastasis and relapse.
Egbulefu C, Black K, Su X, Karmakar P, Habimana-Griffin L, Sudlow G, Prior J, Chukwu E, Zheleznyak A, Xu B, Xu Y, Esser A, Mixdorf M, Moss E, Manion B, Reed N, Gubin M, Lin CY, Schreiber R, Weilbaecher K, Achilefu S. Egbulefu C, et al. Among authors: xu b, xu y. Res Sq [Preprint]. 2024 Mar 12:rs.3.rs-3992212. doi: 10.21203/rs.3.rs-3992212/v1. Res Sq. 2024. PMID: 38558990 Free PMC article. Preprint.
Transferrin receptor in primary and metastatic breast cancer: Evaluation of expression and experimental modulation to improve molecular targeting.
Fontana F, Esser AK, Egbulefu C, Karmakar P, Su X, Allen JS, Xu Y, Davis JL, Gabay A, Xiang J, Kwakwa KA, Manion B, Bakewell S, Li S, Park H, Lanza GM, Achilefu S, Weilbaecher KN. Fontana F, et al. Among authors: xu y. PLoS One. 2023 Dec 20;18(12):e0293700. doi: 10.1371/journal.pone.0293700. eCollection 2023. PLoS One. 2023. PMID: 38117806 Free PMC article.
Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment.
Su X, Xu Y, Fox GC, Xiang J, Kwakwa KA, Davis JL, Belle JI, Lee WC, Wong WH, Fontana F, Hernandez-Aya LF, Kobayashi T, Tomasson HM, Su J, Bakewell SJ, Stewart SA, Egbulefu C, Karmakar P, Meyer MA, Veis DJ, DeNardo DG, Lanza GM, Achilefu S, Weilbaecher KN. Su X, et al. Among authors: xu y. J Clin Invest. 2021 Oct 15;131(20):e145296. doi: 10.1172/JCI145296. J Clin Invest. 2021. PMID: 34520398 Free PMC article.
Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer.
Esser AK, Ross MH, Fontana F, Su X, Gabay A, Fox GC, Xu Y, Xiang J, Schmieder AH, Yang X, Cui G, Scott M, Achilefu S, Chauhan J, Fletcher S, Lanza GM, Weilbaecher KN. Esser AK, et al. Among authors: xu y. Theranostics. 2020 Jun 12;10(17):7510-7526. doi: 10.7150/thno.44523. eCollection 2020. Theranostics. 2020. PMID: 32685002 Free PMC article.
Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases.
Fox GC, Su X, Davis JL, Xu Y, Kwakwa KA, Ross MH, Fontana F, Xiang J, Esser AK, Cordell E, Pagliai K, Dang HX, Sivapackiam J, Stewart SA, Maher CA, Bakewell SJ, Fitzpatrick JAJ, Sharma V, Achilefu S, Veis DJ, Lanza GM, Weilbaecher KN. Fox GC, et al. Among authors: xu y. Mol Cancer Ther. 2021 Jun;20(6):1183-1198. doi: 10.1158/1535-7163.MCT-20-0931. Epub 2021 Mar 30. Mol Cancer Ther. 2021. PMID: 33785647 Free PMC article.
Bone-Induced Expression of Integrin β3 Enables Targeted Nanotherapy of Breast Cancer Metastases.
Ross MH, Esser AK, Fox GC, Schmieder AH, Yang X, Hu G, Pan D, Su X, Xu Y, Novack DV, Walsh T, Colditz GA, Lukaszewicz GH, Cordell E, Novack J, Fitzpatrick JAJ, Waning DL, Mohammad KS, Guise TA, Lanza GM, Weilbaecher KN. Ross MH, et al. Among authors: xu y. Cancer Res. 2017 Nov 15;77(22):6299-6312. doi: 10.1158/0008-5472.CAN-17-1225. Epub 2017 Aug 30. Cancer Res. 2017. PMID: 28855208 Free PMC article.
Antagonizing Integrin β3 Increases Immunosuppression in Cancer.
Su X, Esser AK, Amend SR, Xiang J, Xu Y, Ross MH, Fox GC, Kobayashi T, Steri V, Roomp K, Fontana F, Hurchla MA, Knolhoff BL, Meyer MA, Morgan EA, Tomasson JC, Novack JS, Zou W, Faccio R, Novack DV, Robinson SD, Teitelbaum SL, DeNardo DG, Schneider JG, Weilbaecher KN. Su X, et al. Among authors: xu y. Cancer Res. 2016 Jun 15;76(12):3484-95. doi: 10.1158/0008-5472.CAN-15-2663. Epub 2016 May 23. Cancer Res. 2016. PMID: 27216180 Free PMC article.
HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice.
Esser AK, Rauch DA, Xiang J, Harding JC, Kohart NA, Ross MH, Su X, Wu K, Huey D, Xu Y, Vij K, Green PL, Rosol TJ, Niewiesk S, Ratner L, Weilbaecher KN. Esser AK, et al. Among authors: xu y. Oncotarget. 2017 Aug 27;8(41):69250-69263. doi: 10.18632/oncotarget.20565. eCollection 2017 Sep 19. Oncotarget. 2017. PMID: 29050201 Free PMC article.
HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia.
Xiang J, Rauch DA, Huey DD, Panfil AR, Cheng X, Esser AK, Su X, Harding JC, Xu Y, Fox GC, Fontana F, Kobayashi T, Su J, Sundaramoorthi H, Wong WH, Jia Y, Rosol TJ, Veis DJ, Green PL, Niewiesk S, Ratner L, Weilbaecher KN. Xiang J, et al. Among authors: xu y. JCI Insight. 2019 Oct 3;4(19):e128713. doi: 10.1172/jci.insight.128713. JCI Insight. 2019. PMID: 31578308 Free PMC article.
Hepatic lipids promote liver metastasis.
Li Y, Su X, Rohatgi N, Zhang Y, Brestoff JR, Shoghi KI, Xu Y, Semenkovich CF, Harris CA, Peterson LL, Weilbaecher KN, Teitelbaum SL, Zou W. Li Y, et al. Among authors: xu y. JCI Insight. 2020 Sep 3;5(17):e136215. doi: 10.1172/jci.insight.136215. JCI Insight. 2020. PMID: 32879136 Free PMC article.
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