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OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage.
Tsvilovskyy V, Ottenheijm R, Kriebs U, Schütz A, Diakopoulos KN, Jha A, Bildl W, Wirth A, Böck J, Jaślan D, Ferro I, Taberner FJ, Kalinina O, Hildebrand S, Wissenbach U, Weissgerber P, Vogt D, Eberhagen C, Mannebach S, Berlin M, Kuryshev V, Schumacher D, Philippaert K, Camacho-Londoño JE, Mathar I, Dieterich C, Klugbauer N, Biel M, Wahl-Schott C, Lipp P, Flockerzi V, Zischka H, Algül H, Lechner SG, Lesina M, Grimm C, Fakler B, Schulte U, Muallem S, Freichel M. Tsvilovskyy V, et al. Among authors: philippaert k. J Clin Invest. 2024 Apr 1;134(7):e169428. doi: 10.1172/JCI169428. J Clin Invest. 2024. PMID: 38557489 Free PMC article.
Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial.
Simoens C, Philippaert K, Wuyts C, Goscinny S, Van Hoeck E, Van Loco J, Billen J, de Hoon J, Ampe E, Vangoitsenhoven R, Mertens A, Vennekens R, Van der Schueren B. Simoens C, et al. Among authors: philippaert k. Eur J Drug Metab Pharmacokinet. 2022 Nov;47(6):827-839. doi: 10.1007/s13318-022-00792-7. Epub 2022 Sep 3. Eur J Drug Metab Pharmacokinet. 2022. PMID: 36057030 Free PMC article. Clinical Trial.
TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias.
Vandewiele F, Pironet A, Jacobs G, Kecskés M, Wegener J, Kerselaers S, Hendrikx L, Verelst J, Philippaert K, Oosterlinck W, Segal A, Van Den Broeck E, Pinto S, Priori SG, Lehnart SE, Nilius B, Voets T, Vennekens R. Vandewiele F, et al. Among authors: philippaert k. Eur Heart J. 2022 Oct 21;43(40):4195-4207. doi: 10.1093/eurheartj/ehac354. Eur Heart J. 2022. PMID: 35822895
Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin.
Philippaert K, Kalyaanamoorthy S, Fatehi M, Long W, Soni S, Byrne NJ, Barr A, Singh J, Wong J, Palechuk T, Schneider C, Darwesh AM, Maayah ZH, Seubert JM, Barakat K, Dyck JRB, Light PE. Philippaert K, et al. Circulation. 2021 Jun;143(22):2188-2204. doi: 10.1161/CIRCULATIONAHA.121.053350. Epub 2021 Apr 9. Circulation. 2021. PMID: 33832341 Free PMC article.
Horizontal Hippocampal Slices of the Mouse Brain.
Van Hoeymissen E, Philippaert K, Vennekens R, Vriens J, Held K. Van Hoeymissen E, et al. Among authors: philippaert k. J Vis Exp. 2020 Sep 22;(163). doi: 10.3791/61753. J Vis Exp. 2020. PMID: 33044449
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