Withers SG - Search Results

1

Enzymatic conversion of human blood group A kidneys to universal blood group O.

MacMillan S, Hosgood SA, Walker-Panse L, Rahfeld P, Macdonald SS, Kizhakkedathu JN, Withers SG, Nicholson ML. MacMillan S, et al. Among authors: withers sg. Nat Commun. 2024 Mar 30;15(1):2795. doi: 10.1038/s41467-024-47131-9. Nat Commun. 2024. PMID: 38555382 Free PMC article.

2

Enhancement of biological reactions on cell surfaces via macromolecular crowding.

Chapanian R, Kwan DH, Constantinescu I, Shaikh FA, Rossi NA, Withers SG, Kizhakkedathu JN. Chapanian R, et al. Among authors: withers sg. Nat Commun. 2014 Aug 20;5:4683. doi: 10.1038/ncomms5683. Nat Commun. 2014. PMID: 25140641 Free PMC article.

3

An enzymatic pathway in the human gut microbiome that converts A to universal O type blood.

Rahfeld P, Sim L, Moon H, Constantinescu I, Morgan-Lang C, Hallam SJ, Kizhakkedathu JN, Withers SG. Rahfeld P, et al. Among authors: withers sg. Nat Microbiol. 2019 Sep;4(9):1475-1485. doi: 10.1038/s41564-019-0469-7. Epub 2019 Jun 10. Nat Microbiol. 2019. PMID: 31182795

4

Toward universal donor blood: Enzymatic conversion of A and B to O type.

Rahfeld P, Withers SG. Rahfeld P, et al. Among authors: withers sg. J Biol Chem. 2020 Jan 10;295(2):325-334. doi: 10.1074/jbc.REV119.008164. Epub 2019 Dec 2. J Biol Chem. 2020. PMID: 31792054 Free PMC article. Review.

5

Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs.

Wang A, Ribeiro RVP, Ali A, Brambate E, Abdelnour-Berchtold E, Michaelsen V, Zhang Y, Rahfeld P, Moon H, Gokhale H, Gazzalle A, Pal P, Liu M, Waddell TK, Cserti-Gazdewich C, Tinckam K, Kizhakkedathu JN, West L, Keshavjee S, Withers SG, Cypel M. Wang A, et al. Among authors: withers sg. Sci Transl Med. 2022 Feb 16;14(632):eabm7190. doi: 10.1126/scitranslmed.abm7190. Epub 2022 Feb 16. Sci Transl Med. 2022. PMID: 35171649

6

Carbohydrate-active enzymes (CAZymes) in the gut microbiome.

Wardman JF, Bains RK, Rahfeld P, Withers SG. Wardman JF, et al. Among authors: withers sg. Nat Rev Microbiol. 2022 Sep;20(9):542-556. doi: 10.1038/s41579-022-00712-1. Epub 2022 Mar 28. Nat Rev Microbiol. 2022. PMID: 35347288 Review.

7

Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.

Kwan DH, Constantinescu I, Chapanian R, Higgins MA, Kötzler MP, Samain E, Boraston AB, Kizhakkedathu JN, Withers SG. Kwan DH, et al. Among authors: withers sg. J Am Chem Soc. 2015 May 6;137(17):5695-705. doi: 10.1021/ja5116088. Epub 2015 Apr 24. J Am Chem Soc. 2015. PMID: 25870881

8

Discovery of New Glycosidases From Metagenomic Libraries.

Armstrong Z, Rahfeld P, Withers SG. Armstrong Z, et al. Among authors: withers sg. Methods Enzymol. 2017;597:3-23. doi: 10.1016/bs.mie.2017.06.001. Epub 2017 Jul 29. Methods Enzymol. 2017. PMID: 28935108

9

Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers.

Siren EMJ, Luo HD, Tam F, Montgomery A, Enns W, Moon H, Sim L, Rey K, Guan Q, Wang JJ, Wardell CM, Monajemi M, Mojibian M, Levings MK, Zhang ZJ, Du C, Withers SG, Choy JC, Kizhakkedathu JN. Siren EMJ, et al. Among authors: withers sg. Nat Biomed Eng. 2021 Oct;5(10):1202-1216. doi: 10.1038/s41551-021-00777-y. Epub 2021 Aug 9. Nat Biomed Eng. 2021. PMID: 34373602

10

A Mechanism-Based Approach to Screening Metagenomic Libraries for Discovery of Unconventional Glycosidases.

Nasseri SA, Betschart L, Opaleva D, Rahfeld P, Withers SG. Nasseri SA, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2018 Aug 27;57(35):11359-11364. doi: 10.1002/anie.201806792. Epub 2018 Aug 1. Angew Chem Int Ed Engl. 2018. PMID: 30001477

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