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Automated Patch Clamp Analysis of nAChα7 and Na(V)1.7 Channels.
Obergrussberger A, Haarmann C, Rinke I, Becker N, Guinot D, Brueggemann A, Stoelzle-Feix S, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. Curr Protoc Pharmacol. 2014 Jun 16;65:11.13.1-48. doi: 10.1002/0471141755.ph1113s65. Curr Protoc Pharmacol. 2014. PMID: 24934604
Novel screening techniques for ion channel targeting drugs.
Obergrussberger A, Stölzle-Feix S, Becker N, Brüggemann A, Fertig N, Möller C. Obergrussberger A, et al. Among authors: becker n. Channels (Austin). 2015;9(6):367-75. doi: 10.1080/19336950.2015.1079675. Epub 2015 Nov 10. Channels (Austin). 2015. PMID: 26556400 Free PMC article. Review.
An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery.
Obergrussberger A, Goetze TA, Brinkwirth N, Becker N, Friis S, Rapedius M, Haarmann C, Rinke-Weiß I, Stölzle-Feix S, Brüggemann A, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. Expert Opin Drug Discov. 2018 Mar;13(3):269-277. doi: 10.1080/17460441.2018.1428555. Epub 2018 Jan 17. Expert Opin Drug Discov. 2018. PMID: 29343120 Review.
Safety pharmacology studies using EFP and impedance.
Obergrussberger A, Juhasz K, Thomas U, Stölzle-Feix S, Becker N, Dörr L, Beckler M, Bot C, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:223-32. doi: 10.1016/j.vascn.2016.04.006. Epub 2016 Apr 12. J Pharmacol Toxicol Methods. 2016. PMID: 27084108
A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time.
Goversen B, Becker N, Stoelzle-Feix S, Obergrussberger A, Vos MA, van Veen TAB, Fertig N, de Boer TP. Goversen B, et al. Among authors: becker n. Front Physiol. 2018 Jan 19;8:1094. doi: 10.3389/fphys.2017.01094. eCollection 2017. Front Physiol. 2018. PMID: 29403387 Free PMC article.
The suitability of high throughput automated patch clamp for physiological applications.
Obergrussberger A, Rinke-Weiß I, Goetze TA, Rapedius M, Brinkwirth N, Becker N, Rotordam MG, Hutchison L, Madau P, Pau D, Dalrymple D, Braun N, Friis S, Pless SA, Fertig N. Obergrussberger A, et al. Among authors: becker n. J Physiol. 2022 Jan;600(2):277-297. doi: 10.1113/JP282107. Epub 2021 Oct 8. J Physiol. 2022. PMID: 34555195 Free article.
Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module.
Obergrussberger A, Brüggemann A, Goetze TA, Rapedius M, Haarmann C, Rinke I, Becker N, Oka T, Ohtsuki A, Stengel T, Vogel M, Steindl J, Mueller M, Stiehler J, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. J Lab Autom. 2016 Dec;21(6):779-793. doi: 10.1177/2211068215623209. Epub 2015 Dec 23. J Lab Autom. 2016. PMID: 26702021
1,059 results