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Trimethylation Enhancement Using (13)C-Diazomethane ((13)C-TrEnDi): Increased Sensitivity and Selectivity of Phosphatidylethanolamine, Phosphatidylcholine, and Phosphatidylserine Lipids Derived from Complex Biological Samples.
Canez CR, Shields SW, Bugno M, Wasslen KV, Weinert HP, Willmore WG, Manthorpe JM, Smith JC. Canez CR, et al. Anal Chem. 2016 Jul 19;88(14):6996-7004. doi: 10.1021/acs.analchem.5b04524. Epub 2016 Jun 27. Anal Chem. 2016. PMID: 27275841
First-in-class small molecule potentiators of cancer virotherapy.
Dornan MH, Krishnan R, Macklin AM, Selman M, El Sayes N, Son HH, Davis C, Chen A, Keillor K, Le PJ, Moi C, Ou P, Pardin C, Canez CR, Le Boeuf F, Bell JC, Smith JC, Diallo JS, Boddy CN. Dornan MH, et al. Among authors: canez cr. Sci Rep. 2016 May 26;6:26786. doi: 10.1038/srep26786. Sci Rep. 2016. PMID: 27226390 Free PMC article.
Trimethylation enhancement using diazomethane (TrEnDi) II: rapid in-solution concomitant quaternization of glycerophospholipid amino groups and methylation of phosphate groups via reaction with diazomethane significantly enhances sensitivity in mass spectrometry analyses via a fixed, permanent positive charge.
Wasslen KV, Canez CR, Lee H, Manthorpe JM, Smith JC. Wasslen KV, et al. Among authors: canez cr. Anal Chem. 2014 Oct 7;86(19):9523-32. doi: 10.1021/ac501588y. Epub 2014 Sep 24. Anal Chem. 2014. PMID: 25208053