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Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA.
van Soest DMK, Polderman PE, den Toom WTF, Keijer JP, van Roosmalen MJ, Leyten TMF, Lehmann J, Zwakenberg S, De Henau S, van Boxtel R, Burgering BMT, Dansen TB. van Soest DMK, et al. Among authors: van boxtel r. Nat Commun. 2024 Mar 28;15(1):2725. doi: 10.1038/s41467-024-47008-x. Nat Commun. 2024. PMID: 38548751 Free PMC article.
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy.
van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, Verhagen LP, Groot Koerkamp MJ, Braat AK, Dansen TB, Holstege FC, Gebhardt R, Burgering BM, Coffer PJ. van der Vos KE, et al. Among authors: van boxtel r, van zutphen ij. Nat Cell Biol. 2012 Aug;14(8):829-37. doi: 10.1038/ncb2536. Epub 2012 Jul 22. Nat Cell Biol. 2012. PMID: 22820375
MutationalPatterns: the one stop shop for the analysis of mutational processes.
Manders F, Brandsma AM, de Kanter J, Verheul M, Oka R, van Roosmalen MJ, van der Roest B, van Hoeck A, Cuppen E, van Boxtel R. Manders F, et al. Among authors: van hoeck a, van boxtel r, van roosmalen mj, van der roest b. BMC Genomics. 2022 Feb 15;23(1):134. doi: 10.1186/s12864-022-08357-3. BMC Genomics. 2022. PMID: 35168570 Free PMC article.
Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms.
Bertrums EJM, Rosendahl Huber AKM, de Kanter JK, Brandsma AM, van Leeuwen AJCN, Verheul M, van den Heuvel-Eibrink MM, Oka R, van Roosmalen MJ, de Groot-Kruseman HA, Zwaan CM, Goemans BF, van Boxtel R. Bertrums EJM, et al. Among authors: van den heuvel eibrink mm, van leeuwen ajcn, van boxtel r, van roosmalen mj. Cancer Discov. 2022 Aug 5;12(8):1860-1872. doi: 10.1158/2159-8290.CD-22-0120. Cancer Discov. 2022. PMID: 35678530 Free PMC article.
Mutation signatures of pediatric acute myeloid leukemia and normal blood progenitors associated with differential patient outcomes.
Brandsma AM, Bertrums EJM, van Roosmalen MJ, Hofman DA, Oka R, Verheul M, Manders F, Ubels J, Belderbos ME, van Boxtel R. Brandsma AM, et al. Among authors: van boxtel r, van roosmalen mj. Blood Cancer Discov. 2021 Sep;2(5):484-499. doi: 10.1158/2643-3230.BCD-21-0010. Blood Cancer Discov. 2021. PMID: 34642666 Free PMC article.
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients.
de Kanter JK, Peci F, Bertrums E, Rosendahl Huber A, van Leeuwen A, van Roosmalen MJ, Manders F, Verheul M, Oka R, Brandsma AM, Bierings M, Belderbos M, van Boxtel R. de Kanter JK, et al. Among authors: van boxtel r, van roosmalen mj, van leeuwen a. Cell Stem Cell. 2021 Oct 7;28(10):1726-1739.e6. doi: 10.1016/j.stem.2021.07.012. Epub 2021 Sep 7. Cell Stem Cell. 2021. PMID: 34496298 Free PMC article.
Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer.
Rosendahl Huber A, Pleguezuelos-Manzano C, Puschhof J, Ubels J, Boot C, Saftien A, Verheul M, Trabut LT, Groenen N, van Roosmalen M, Ouyang KS, Wood H, Quirke P, Meijer G, Cuppen E, Clevers H, van Boxtel R. Rosendahl Huber A, et al. Among authors: van boxtel r. Cancer Cell. 2024 Mar 11;42(3):487-496.e6. doi: 10.1016/j.ccell.2024.02.009. Cancer Cell. 2024. PMID: 38471458 Free article.
Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox.
Middelkamp S, Manders F, Peci F, van Roosmalen MJ, González DM, Bertrums EJM, van der Werf I, Derks LLM, Groenen NM, Verheul M, Trabut L, Pleguezuelos-Manzano C, Brandsma AM, Antoniou E, Reinhardt D, Bierings M, Belderbos ME, van Boxtel R. Middelkamp S, et al. Among authors: van boxtel r. Cell Genom. 2023 Aug 23;3(9):100389. doi: 10.1016/j.xgen.2023.100389. eCollection 2023 Sep 13. Cell Genom. 2023. PMID: 37719152 Free PMC article.
The mutational impact of culturing human pluripotent and adult stem cells.
Kuijk E, Jager M, van der Roest B, Locati MD, Van Hoeck A, Korzelius J, Janssen R, Besselink N, Boymans S, van Boxtel R, Cuppen E. Kuijk E, et al. Among authors: van hoeck a, van boxtel r, van der roest b. Nat Commun. 2020 May 19;11(1):2493. doi: 10.1038/s41467-020-16323-4. Nat Commun. 2020. PMID: 32427826 Free PMC article.
140 results