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The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse.
Lesinski GB, Anghelina M, Zimmerer J, Bakalakos T, Badgwell B, Parihar R, Hu Y, Becknell B, Abood G, Chaudhury AR, Magro C, Durbin J, Carson WE 3rd. Lesinski GB, et al. Among authors: hu y. J Clin Invest. 2003 Jul;112(2):170-80. doi: 10.1172/JCI16603. J Clin Invest. 2003. PMID: 12865406 Free PMC article.
Administration of two macrophage-derived interferon-gamma-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-gamma.
Biber JL, Jabbour S, Parihar R, Dierksheide J, Hu Y, Baumann H, Bouchard P, Caligiuri MA, Carson W. Biber JL, et al. Among authors: hu y. Cell Immunol. 2002 Mar-Apr;216(1-2):31-42. doi: 10.1016/s0008-8749(02)00501-4. Cell Immunol. 2002. PMID: 12381348
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