Lim HK - Search Results

1

Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs.

Shang J, Coe KJ, Lim HK, Chen L, Khatri BB, Salter R, Mitra K, Iyer R. Shang J, et al. Among authors: lim hk. Chem Res Toxicol. 2024 Apr 15;37(4):540-544. doi: 10.1021/acs.chemrestox.4c00046. Epub 2024 Mar 26. Chem Res Toxicol. 2024. PMID: 38530825

2

Overcoming the genotoxicity of a pyrrolidine substituted arylindenopyrimidine as a potent dual adenosine A(2A)/A(1) antagonist by minimizing bioactivation to an iminium ion reactive intermediate.

Lim HK, Chen J, Sensenhauser C, Cook K, Preston R, Thomas T, Shook B, Jackson PF, Rassnick S, Rhodes K, Gopaul V, Salter R, Silva J, Evans DC. Lim HK, et al. Chem Res Toxicol. 2011 Jul 18;24(7):1012-30. doi: 10.1021/tx1004437. Epub 2011 Jun 28. Chem Res Toxicol. 2011. PMID: 21667953

3

Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury.

Otieno MA, Snoeys J, Lam W, Ghosh A, Player MR, Pocai A, Salter R, Simic D, Skaggs H, Singh B, Lim HK. Otieno MA, et al. Among authors: lim hk. Toxicol Sci. 2018 Jun 1;163(2):374-384. doi: 10.1093/toxsci/kfx040. Toxicol Sci. 2018. PMID: 28206647

4

Reductive Desulfuration as an Important Tool in Detection of Small Molecule Modifications to Payload of Antibody Drug Conjugates.

Wang J, Zhang W, Salter R, Lim HK. Wang J, et al. Among authors: lim hk. Anal Chem. 2019 Feb 5;91(3):2368-2375. doi: 10.1021/acs.analchem.8b05134. Epub 2019 Jan 15. Anal Chem. 2019. PMID: 30609358

5

Bifunctionalized isotopologs as calibrants for standard-free quantitation of drug metabolites in plasma by liquid chromatography coupled with radiometry and mass spectrometry.

Gong Y, Chen J, Lim HK, Weng N, Salter R. Gong Y, et al. Among authors: lim hk. Biomed Chromatogr. 2022 Jan;36(1):e5242. doi: 10.1002/bmc.5242. Epub 2021 Oct 3. Biomed Chromatogr. 2022. PMID: 34519061

6

Standard-Free Bioanalytical Approach for Absolute Quantitation of Drug Metabolites Utilizing Biosynthesis of Reciprocal Radio and Stable Isotopologues and Its Application.

Gong Y, Chen J, Shi Y, Lim HK, Weng N, Salter R. Gong Y, et al. Among authors: lim hk. Anal Chem. 2017 Aug 15;89(16):8399-8404. doi: 10.1021/acs.analchem.7b01830. Epub 2017 Jul 25. Anal Chem. 2017. PMID: 28696683

7

Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans.

Lim HK, Chen J, Lam W, Gong Y, Leclercq L, Silva J, Salter R, Berwaerts J, Gelotte CK, Vakil AM, Eichenbaum GE, Kuffner EK, Flores CM. Lim HK, et al. Regul Toxicol Pharmacol. 2023 Mar 16:105379. doi: 10.1016/j.yrtph.2023.105379. Online ahead of print. Regul Toxicol Pharmacol. 2023. PMID: 36931586 Free article.

8

Bio-generation of stable isotope labeled internal standards for absolute and relative quantitation of drug metabolites in plasma samples by LC-MS/MS.

Li P, Gong Y, Lim HK, Jian W, Edom RW, Salter R, Silva J, Weng N. Li P, et al. Among authors: lim hk. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 May 1;926:92-100. doi: 10.1016/j.jchromb.2013.03.006. Epub 2013 Mar 16. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23562907

9

Cytochrome P450 induction response in tethered spheroids as a three-dimensional human hepatocyte in vitro model.

Xia L, Hong X, Sakban RB, Qu Y, Singh NH, McMillian M, Dallas S, Silva J, Sensenhauser C, Zhao S, Lim HK, Yu H. Xia L, et al. Among authors: lim hk. J Appl Toxicol. 2016 Feb;36(2):320-9. doi: 10.1002/jat.3189. Epub 2015 Jul 21. J Appl Toxicol. 2016. PMID: 26201057

10

Design and characterization of optimized adenosine A₂A/A₁ receptor antagonists for the treatment of Parkinson's disease.

Shook BC, Rassnick S, Wallace N, Crooke J, Ault M, Chakravarty D, Barbay JK, Wang A, Powell MT, Leonard K, Alford V, Scannevin RH, Carroll K, Lampron L, Westover L, Lim HK, Russell R, Branum S, Wells KM, Damon S, Youells S, Li X, Beauchamp DA, Rhodes K, Jackson PF. Shook BC, et al. Among authors: lim hk. J Med Chem. 2012 Feb 9;55(3):1402-17. doi: 10.1021/jm201640m. Epub 2012 Jan 26. J Med Chem. 2012. PMID: 22239465

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