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Targeting metabolic adaptive responses induced by glucose starvation inhibits cell proliferation and enhances cell death in osimertinib-resistant non-small cell lung cancer (NSCLC) cell lines.
Eltayeb K, Alfieri R, Fumarola C, Bonelli M, Galetti M, Cavazzoni A, Digiacomo G, Galvani F, Vacondio F, Lodola A, Mor M, Minari R, Tiseo M, La Monica S, Giorgio Petronini P. Eltayeb K, et al. Among authors: vacondio f. Biochem Pharmacol. 2024 Mar 24:116161. doi: 10.1016/j.bcp.2024.116161. Online ahead of print. Biochem Pharmacol. 2024. PMID: 38522556 Free article.
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.
La Monica S, Vacondio F, Eltayeb K, Lodola A, Volta F, Viglioli M, Ferlenghi F, Galvani F, Galetti M, Bonelli M, Fumarola C, Cavazzoni A, Flammini L, Verzè M, Minari R, Petronini PG, Tiseo M, Mor M, Alfieri R. La Monica S, et al. Among authors: vacondio f. Sci Rep. 2024 Mar 18;14(1):6491. doi: 10.1038/s41598-024-57028-8. Sci Rep. 2024. PMID: 38499619 Free PMC article.
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats.
Barbetti M, Mancabelli L, Vacondio F, Longhi G, Ferlenghi F, Viglioli M, Turroni F, Carnevali L, Mor M, Ventura M, Sgoifo A, Rivara S. Barbetti M, et al. Among authors: vacondio f. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Apr 20;131:110963. doi: 10.1016/j.pnpbp.2024.110963. Epub 2024 Feb 12. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 38354897 Free article.
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity.
Guidetti L, Zappia A, Scalvini L, Ferrari FR, Giorgio C, Castelli R, Galvani F, Vacondio F, Rivara S, Mor M, Urbinati C, Rusnati M, Tognolini M, Lodola A. Guidetti L, et al. Among authors: vacondio f. J Chem Inf Model. 2023 Nov 13;63(21):6900-6911. doi: 10.1021/acs.jcim.3c01064. Epub 2023 Nov 1. J Chem Inf Model. 2023. PMID: 37910792 Free PMC article.
Disentangling the interactions between nasopharyngeal and gut microbiome and their involvement in the modulation of COVID-19 infection.
Mancabelli L, Taurino G, Ticinesi A, Ciociola T, Vacondio F, Milani C, Fontana F, Lugli GA, Tarracchini C, Alessandri G, Viappiani A, Bianchi M, Nouvenne A, Chetta AA, Turroni F, Meschi T, Mor M, Bussolati O, Ventura M. Mancabelli L, et al. Among authors: vacondio f. Microbiol Spectr. 2023 Sep 20;11(5):e0219423. doi: 10.1128/spectrum.02194-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 37728335 Free PMC article.
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Mugnaini C, Kostrzewa M, Casini M, Kumar P, Catallo V, Allarà M, Guastaferro L, Brizzi A, Paolino M, Tafi A, Kapatais C, Giorgi G, Vacondio F, Mor M, Corelli F, Ligresti A. Mugnaini C, et al. Among authors: vacondio f. Molecules. 2023 Jun 24;28(13):4958. doi: 10.3390/molecules28134958. Molecules. 2023. PMID: 37446625 Free PMC article.
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit-to-lead optimization and release of a novel antitubercular chemotype via scaffold derivatization.
Girardini M, Ferlenghi F, Annunziato G, Degiacomi G, Papotti B, Marchi C, Sammartino JC, Rasheed SS, Contini A, Pasca MR, Vacondio F, Evans JC, Dick T, Müller R, Costantino G, Pieroni M. Girardini M, et al. Among authors: vacondio f. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114916. doi: 10.1016/j.ejmech.2022.114916. Epub 2022 Nov 11. Eur J Med Chem. 2023. PMID: 36399878 Free PMC article.
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph-Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice.
Ferlenghi F, Giorgio C, Incerti M, Guidetti L, Chiodelli P, Rusnati M, Tognolini M, Vacondio F, Mor M, Lodola A. Ferlenghi F, et al. Among authors: vacondio f. Pharmaceuticals (Basel). 2021 Dec 28;15(1):41. doi: 10.3390/ph15010041. Pharmaceuticals (Basel). 2021. PMID: 35056098 Free PMC article.
84 results