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Trimethylamine N-oxide impairs β-cell function and glucose tolerance.
Kong L, Zhao Q, Jiang X, Hu J, Jiang Q, Sheng L, Peng X, Wang S, Chen Y, Wan Y, Hou S, Liu X, Ma C, Li Y, Quan L, Chen L, Cui B, Li P. Kong L, et al. Among authors: chen l, chen y. Nat Commun. 2024 Mar 21;15(1):2526. doi: 10.1038/s41467-024-46829-0. Nat Commun. 2024. PMID: 38514666 Free PMC article.
Pancreatic α and β cells are globally phase-locked.
Ren H, Li Y, Han C, Yu Y, Shi B, Peng X, Zhang T, Wu S, Yang X, Kim S, Chen L, Tang C. Ren H, et al. Among authors: chen l. Nat Commun. 2022 Jun 28;13(1):3721. doi: 10.1038/s41467-022-31373-6. Nat Commun. 2022. PMID: 35764654 Free PMC article.
Readily releasable β cells with tight Ca2+-exocytosis coupling dictate biphasic glucose-stimulated insulin secretion.
Peng X, Ren H, Yang L, Tong S, Zhou R, Long H, Wu Y, Wang L, Wu Y, Zhang Y, Shen J, Zhang J, Qiu G, Wang J, Han C, Zhang Y, Zhou M, Zhao Y, Xu T, Tang C, Chen Z, Liu H, Chen L. Peng X, et al. Among authors: chen z, chen l. Nat Metab. 2024 Feb;6(2):238-253. doi: 10.1038/s42255-023-00962-0. Epub 2024 Jan 26. Nat Metab. 2024. PMID: 38278946
Galectin-3 impairs calcium transients and β-cell function.
Jiang Q, Zhao Q, Chen Y, Ma C, Peng X, Wu X, Liu X, Wang R, Hou S, Kong L, Wan Y, Wang S, Meng ZX, Cui B, Chen L, Li P. Jiang Q, et al. Among authors: chen l, chen y. Nat Commun. 2024 May 1;15(1):3682. doi: 10.1038/s41467-024-47959-1. Nat Commun. 2024. PMID: 38693121 Free PMC article.
Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders.
Xiao Y, Wang C, Chen JY, Lu F, Wang J, Hou N, Hu X, Zeng F, Ma D, Sun X, Ding Y, Zhang Y, Zheng W, Liu Y, Shang H, Zhu W, Han C, Zhang Y, Ouyang K, Chen L, Chen J, Xiao RP, Li CY, Zhang X. Xiao Y, et al. Among authors: chen j, chen l, chen jy. Nat Commun. 2018 May 22;9(1):2015. doi: 10.1038/s41467-018-04352-z. Nat Commun. 2018. PMID: 29789568 Free PMC article.
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