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Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.
Concato-Lopes VM, Gonçalves-Lens MD, Tomiotto-Pellissier F, Detoni MB, Cruz EMS, Bortoleti BTDS, Carloto ACM, Rodrigues ACJ, Silva TF, Siqueira EDS, de Matos RLN, Alves Cardoso IL, Conchon-Costa I, Lazarin-Bidóia D, Arakawa NS, Dekker RFH, Mantovani MS, Pavanelli WR. Concato-Lopes VM, et al. Among authors: siqueira eds. Phytomedicine. 2024 Jun;128:155536. doi: 10.1016/j.phymed.2024.155536. Epub 2024 Mar 13. Phytomedicine. 2024. PMID: 38513379
Trans-chalcone induces death by autophagy mediated by p53 up-regulation and β-catenin down-regulation on human hepatocellular carcinoma HuH7.5 cell line.
Siqueira EDS, Concato VM, Tomiotto-Pellissier F, Silva TF, Bortoleti BTDS, Gonçalves MD, Costa IN, Junior WAV, Pavanelli WR, Panis C, Mantovani MS, Miranda-Sapla MM, Conchon-Costa I. Siqueira EDS, et al. Phytomedicine. 2021 Jan;80:153373. doi: 10.1016/j.phymed.2020.153373. Epub 2020 Oct 9. Phytomedicine. 2021. PMID: 33096451
3,3',5,5'-tetramethoxybiphenyl-4,4'diol induces cell cycle arrest in G2/M phase and apoptosis in human non-small cell lung cancer A549 cells.
Concato VM, Tomiotto-Pellissier F, Silva TF, Gonçalves MD, Bortoleti BTDS, Detoni MB, Siqueira EDS, Rodrigues ACJ, Schirmann JG, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Mantovani MS, Pavanelli WR. Concato VM, et al. Among authors: siqueira eds. Chem Biol Interact. 2020 Aug 1;326:109133. doi: 10.1016/j.cbi.2020.109133. Epub 2020 May 24. Chem Biol Interact. 2020. PMID: 32461103
A 21st Century Evil: Immunopathology and New Therapies of COVID-19.
Silva TF, Tomiotto-Pellissier F, Sanfelice RA, Gonçalves MD, da Silva Bortoleti BT, Detoni MB, Rodrigues ACJ, Carloto ACM, Concato VM, Siqueira EDS, Costa IN, Pavanelli WR, Conchon-Costa I, Miranda-Sapla MM. Silva TF, et al. Among authors: siqueira eds. Front Immunol. 2020 Oct 27;11:562264. doi: 10.3389/fimmu.2020.562264. eCollection 2020. Front Immunol. 2020. PMID: 33193331 Free PMC article. Review.