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Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.
Concato-Lopes VM, Gonçalves-Lens MD, Tomiotto-Pellissier F, Detoni MB, Cruz EMS, Bortoleti BTDS, Carloto ACM, Rodrigues ACJ, Silva TF, Siqueira EDS, de Matos RLN, Alves Cardoso IL, Conchon-Costa I, Lazarin-Bidóia D, Arakawa NS, Dekker RFH, Mantovani MS, Pavanelli WR. Concato-Lopes VM, et al. Among authors: rodrigues acj. Phytomedicine. 2024 Jun;128:155536. doi: 10.1016/j.phymed.2024.155536. Epub 2024 Mar 13. Phytomedicine. 2024. PMID: 38513379
Solidagenone acts on promastigotes of L. amazonensis by inducing apoptosis-like processes on intracellular amastigotes by IL-12p70/ROS/NO pathway activation.
Bortoleti BTDS, Gonçalves MD, Tomiotto-Pellissier F, Contato VM, Silva TF, de Matos RLN, Detoni MB, Rodrigues ACJ, Carloto AC, Lazarin DB, Arakawa NS, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Wowk PF, Pavanelli WR. Bortoleti BTDS, et al. Among authors: rodrigues acj. Phytomedicine. 2021 May;85:153536. doi: 10.1016/j.phymed.2021.153536. Epub 2021 Mar 3. Phytomedicine. 2021. PMID: 33765552
3,3',5,5'-Tetramethoxybiphenyl-4,4'diol triggers oxidative stress, metabolic changes, and apoptosis-like process by reducing the PI3K/AKT/NF-κB pathway in the NCI-H460 lung cancer cell line.
Concato-Lopes VM, Silva TF, Detoni MB, Cruz EMS, Gonçalves MD, da Silva Bortoleti BT, Tomiotto-Pellissier F, Carloto ACM, Madureira MB, Rodrigues ACJ, Schirmann JG, Barbosa-Dekker AM, Dekker RFH, Conchon-Costa I, Panis C, Lazarin-Bidóia D, Miranda-Sapla MM, Mantovani MS, Pavanelli WR. Concato-Lopes VM, et al. Among authors: rodrigues acj. Biomed Pharmacother. 2024 Jan;170:115979. doi: 10.1016/j.biopha.2023.115979. Epub 2023 Dec 6. Biomed Pharmacother. 2024. PMID: 38061138 Free article.
3,3',5,5'-tetramethoxybiphenyl-4,4'diol induces cell cycle arrest in G2/M phase and apoptosis in human non-small cell lung cancer A549 cells.
Concato VM, Tomiotto-Pellissier F, Silva TF, Gonçalves MD, Bortoleti BTDS, Detoni MB, Siqueira EDS, Rodrigues ACJ, Schirmann JG, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Mantovani MS, Pavanelli WR. Concato VM, et al. Among authors: rodrigues acj. Chem Biol Interact. 2020 Aug 1;326:109133. doi: 10.1016/j.cbi.2020.109133. Epub 2020 May 24. Chem Biol Interact. 2020. PMID: 32461103
Larval excretion/secretion of dipters of Lucilia cuprina species induces death in promastigote and amastigote forms of Leishmania amazonensis.
Rodrigues ACJ, Bortoleti BTDS, Carloto ACM, Silva TF, Concato VM, Gonçalves MD, Tomiotto-Pelissier F, Detoni MB, Diaz-Roa A, Júnior PIDS, Costa IN, Conchon-Costa I, Bidoia DL, Miranda-Sapla MM, Pavanelli WR. Rodrigues ACJ, et al. Pathog Dis. 2021 Aug 10;79(6):ftab040. doi: 10.1093/femspd/ftab040. Pathog Dis. 2021. PMID: 34347083
Grandiflorenic acid isolated from Sphagneticola trilobata against Trypanosoma cruzi: Toxicity, mechanisms of action and immunomodulation.
Gonçalves MD, Bortoleti BTDS, Tomiotto-Pellissier F, Concato VM, de Matos RLN, Silva TF, Rodrigues ACJ, Carloto ACM, Costa IN, Lazarin-Bidóia D, Miranda-Sapla MM, Pavanelli WR, Arakawa NS, Conchon-Costa I. Gonçalves MD, et al. Among authors: rodrigues acj. Toxicol In Vitro. 2022 Feb;78:105267. doi: 10.1016/j.tiv.2021.105267. Epub 2021 Oct 22. Toxicol In Vitro. 2022. PMID: 34688839
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules.
Carloto ACM, Bortoleti BTDS, Rodrigues ACJ, Silva TF, Tomiotto-Pellissier F, Bidóia DL, Gonçalves MD, Assolini JP, Dekker RFH, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Carloto ACM, et al. Among authors: rodrigues acj. Chem Biol Interact. 2022 Jan 5;351:109713. doi: 10.1016/j.cbi.2021.109713. Epub 2021 Oct 23. Chem Biol Interact. 2022. PMID: 34699765
Solidagenone in vivo leishmanicidal activity acting in tissue repair response, and immunomodulatory capacity in Leishmania amazonensis.
Bortoleti BTDS, Detoni MB, Gonçalves MD, Tomiotto-Pellissier F, Silva TF, Concato VM, Rodrigues ACJ, Carloto AC, de Matos RLN, Fattori V, Arakawa NS, Verri WA Jr, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Wowk PF, Pavanelli WR. Bortoleti BTDS, et al. Among authors: rodrigues acj. Chem Biol Interact. 2022 Jul 1;361:109969. doi: 10.1016/j.cbi.2022.109969. Epub 2022 May 5. Chem Biol Interact. 2022. PMID: 35526601
Biogenic silver nanoparticle exhibits schistosomicidal activity in vitro and reduces the parasitic burden in experimental schistosomiasis mansoni.
Detoni MB, Bortoleti BTDS, Tomiotto-Pellissier F, Concato VM, Gonçalves MD, Silva TF, Ortiz LSF, Gomilde AC, Rodrigues ACJ, de Matos RLN, Bracarense APFRL, de Matos AMRN, Simão ANC, Endo TH, Kobayashi RKT, Nakazato G, Costa IN, Conchon-Costa I, Oliveira FJA, Pavanelli WR, Miranda-Sapla MM. Detoni MB, et al. Among authors: rodrigues acj. Microbes Infect. 2023 Sep-Oct;25(7):105145. doi: 10.1016/j.micinf.2023.105145. Epub 2023 Apr 28. Microbes Infect. 2023. PMID: 37120010
Synergistic Antileishmanial Effect of Oregano Essential Oil and Silver Nanoparticles: Mechanisms of Action on Leishmania amazonensis.
Alves AB, da Silva Bortoleti BT, Tomiotto-Pellissier F, Ganaza AFM, Gonçalves MD, Carloto ACM, Rodrigues ACJ, Silva TF, Nakazato G, Kobayashi RKT, Lazarin-Bidóia D, Miranda-Sapla MM, Costa IN, Pavanelli WR, Conchon-Costa I. Alves AB, et al. Among authors: rodrigues acj. Pathogens. 2023 Apr 29;12(5):660. doi: 10.3390/pathogens12050660. Pathogens. 2023. PMID: 37242330 Free PMC article.
16 results