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Trilobolide-6-O-isobutyrate from Sphagneticola trilobata acts by inducing oxidative stress, metabolic changes and apoptosis-like processes by caspase 3/7 activation of human lung cancer cell lines.
Concato-Lopes VM, Gonçalves-Lens MD, Tomiotto-Pellissier F, Detoni MB, Cruz EMS, Bortoleti BTDS, Carloto ACM, Rodrigues ACJ, Silva TF, Siqueira EDS, de Matos RLN, Alves Cardoso IL, Conchon-Costa I, Lazarin-Bidóia D, Arakawa NS, Dekker RFH, Mantovani MS, Pavanelli WR. Concato-Lopes VM, et al. Among authors: bortoleti btds. Phytomedicine. 2024 Jun;128:155536. doi: 10.1016/j.phymed.2024.155536. Epub 2024 Mar 13. Phytomedicine. 2024. PMID: 38513379
Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response.
Silva TF, Detoni MB, Concato-Lopes VM, Tomiotto-Pellissier F, Miranda-Sapla MM, Bortoleti BTDS, Gonçalves MD, Rodrigues ACJ, Sanfelice RA, Cruz EMS, Silva MSDS, Carloto ACM, Bidoia DL, Costa IN, Pavanelli WR, Conchon-Costa I. Silva TF, et al. Among authors: bortoleti btds. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167078. doi: 10.1016/j.bbadis.2024.167078. Epub 2024 Feb 15. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38364941
Biogenic silver nanoparticle exhibits schistosomicidal activity in vitro and reduces the parasitic burden in experimental schistosomiasis mansoni.
Detoni MB, Bortoleti BTDS, Tomiotto-Pellissier F, Concato VM, Gonçalves MD, Silva TF, Ortiz LSF, Gomilde AC, Rodrigues ACJ, de Matos RLN, Bracarense APFRL, de Matos AMRN, Simão ANC, Endo TH, Kobayashi RKT, Nakazato G, Costa IN, Conchon-Costa I, Oliveira FJA, Pavanelli WR, Miranda-Sapla MM. Detoni MB, et al. Among authors: bortoleti btds. Microbes Infect. 2023 Sep-Oct;25(7):105145. doi: 10.1016/j.micinf.2023.105145. Epub 2023 Apr 28. Microbes Infect. 2023. PMID: 37120010
Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis.
de Santiago-Silva KM, Bortoleti BTDS, Oliveira LDN, Maia FLA, Castro JC, Costa IC, Lazarin DB, Wardell JL, Wardell SMSV, Albuquerque MG, Lima CHDS, Pavanelli WR, Bispo MLF, Gonçalves RSB. de Santiago-Silva KM, et al. Among authors: bortoleti btds. Antibiotics (Basel). 2022 Oct 13;11(10):1402. doi: 10.3390/antibiotics11101402. Antibiotics (Basel). 2022. PMID: 36290060 Free PMC article.
Solidagenone in vivo leishmanicidal activity acting in tissue repair response, and immunomodulatory capacity in Leishmania amazonensis.
Bortoleti BTDS, Detoni MB, Gonçalves MD, Tomiotto-Pellissier F, Silva TF, Concato VM, Rodrigues ACJ, Carloto AC, de Matos RLN, Fattori V, Arakawa NS, Verri WA Jr, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Wowk PF, Pavanelli WR. Bortoleti BTDS, et al. Chem Biol Interact. 2022 Jul 1;361:109969. doi: 10.1016/j.cbi.2022.109969. Epub 2022 May 5. Chem Biol Interact. 2022. PMID: 35526601
Nanomedicine in leishmaniasis: A promising tool for diagnosis, treatment and prevention of disease - An update overview.
Assolini JP, Carloto ACM, Bortoleti BTDS, Gonçalves MD, Tomiotto Pellissier F, Feuser PE, Cordeiro AP, Hermes de Araújo PH, Sayer C, Miranda Sapla MM, Pavanelli WR. Assolini JP, et al. Among authors: bortoleti btds. Eur J Pharmacol. 2022 May 15;923:174934. doi: 10.1016/j.ejphar.2022.174934. Epub 2022 Mar 31. Eur J Pharmacol. 2022. PMID: 35367420 Review.
Biogenic silver nanoparticles reduce Toxoplasma gondii infection and proliferation in RAW 264.7 macrophages by inducing tumor necrosis factor-alpha and reactive oxygen species production in the cells.
Arruda da Silva Sanfelice R, Silva TF, Tomiotto-Pellissier F, Bortoleti BTDS, Lazarin-Bidóia D, Scandorieiro S, Nakazato G, de Barros LD, Garcia JL, Verri WA, Conchon-Costa I, Pavanelli WR, Costa IN. Arruda da Silva Sanfelice R, et al. Among authors: bortoleti btds. Microbes Infect. 2022 Jul-Aug;24(5):104971. doi: 10.1016/j.micinf.2022.104971. Epub 2022 Mar 25. Microbes Infect. 2022. PMID: 35341976 Free article.
Corrigendum: Murine Susceptibility to Leishmania amazonensis Infection Is Influenced by Arginase-1 and Macrophages at the Lesion Site.
Tomiotto-Pellissier F, Miranda-Sapla MM, Silva TF, Bortoleti BTDS, Gonçalves MD, Concato VM, Rodrigues ACJ, Detoni MB, Staurengo-Ferrari L, Verri WA Jr, Costa IN, Panis C, Conchon-Costa I, Bordignon J, Pavanelli WR. Tomiotto-Pellissier F, et al. Among authors: bortoleti btds. Front Cell Infect Microbiol. 2022 Feb 24;11:804809. doi: 10.3389/fcimb.2021.804809. eCollection 2021. Front Cell Infect Microbiol. 2022. PMID: 35282594 Free PMC article.
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules.
Carloto ACM, Bortoleti BTDS, Rodrigues ACJ, Silva TF, Tomiotto-Pellissier F, Bidóia DL, Gonçalves MD, Assolini JP, Dekker RFH, Barbosa-Dekker AM, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Carloto ACM, et al. Among authors: bortoleti btds. Chem Biol Interact. 2022 Jan 5;351:109713. doi: 10.1016/j.cbi.2021.109713. Epub 2021 Oct 23. Chem Biol Interact. 2022. PMID: 34699765
Grandiflorenic acid isolated from Sphagneticola trilobata against Trypanosoma cruzi: Toxicity, mechanisms of action and immunomodulation.
Gonçalves MD, Bortoleti BTDS, Tomiotto-Pellissier F, Concato VM, de Matos RLN, Silva TF, Rodrigues ACJ, Carloto ACM, Costa IN, Lazarin-Bidóia D, Miranda-Sapla MM, Pavanelli WR, Arakawa NS, Conchon-Costa I. Gonçalves MD, et al. Among authors: bortoleti btds. Toxicol In Vitro. 2022 Feb;78:105267. doi: 10.1016/j.tiv.2021.105267. Epub 2021 Oct 22. Toxicol In Vitro. 2022. PMID: 34688839
27 results