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COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history.
Townsley H, Gahir J, Russell TW, Greenwood D, Carr EJ, Dyke M, Adams L, Miah M, Clayton B, Smith C, Miranda M, Mears HV, Bailey C, Black JRM, Fowler AS, Crawford M, Wilkinson K, Hutchinson M, Harvey R, O'Reilly N, Kelly G, Goldstone R, Beale R, Papineni P, Corrah T, Gilson R, Caidan S, Nicod J, Gamblin S, Kassiotis G, Libri V, Williams B, Gandhi S, Kucharski AJ, Swanton C, Bauer DLV, Wall EC. Townsley H, et al. Among authors: o reilly n. PLoS One. 2024 Mar 21;19(3):e0294897. doi: 10.1371/journal.pone.0294897. eCollection 2024. PLoS One. 2024. PMID: 38512960 Free PMC article.
Within-host SARS-CoV-2 viral kinetics informed by complex life course exposures reveals different intrinsic properties of Omicron and Delta variants.
Russell TW, Townsley H, Abbott S, Hellewell J, Carr EJ, Chapman L, Pung R, Quilty BJ, Hodgson D, Fowler AS, Adams L, Bailey C, Mears HV, Harvey R, Clayton B, O'Reilly N, Ngai Y, Nicod J, Gamblin S, Williams B, Gandhi S, Swanton C, Beale R, Bauer DL, Wall EC, Kucharski A. Russell TW, et al. medRxiv [Preprint]. 2023 May 24:2023.05.17.23290105. doi: 10.1101/2023.05.17.23290105. medRxiv. 2023. PMID: 37292842 Free PMC article. Preprint.
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants.
Russell TW, Townsley H, Abbott S, Hellewell J, Carr EJ, Chapman LAC, Pung R, Quilty BJ, Hodgson D, Fowler AS, Adams L, Bailey C, Mears HV, Harvey R, Clayton B, O'Reilly N, Ngai Y, Nicod J, Gamblin S, Williams B, Gandhi S, Swanton C, Beale R, Bauer DLV, Wall EC, Kucharski AJ. Russell TW, et al. Among authors: o reilly n. PLoS Biol. 2024 Jan 30;22(1):e3002463. doi: 10.1371/journal.pbio.3002463. eCollection 2024 Jan. PLoS Biol. 2024. PMID: 38289907 Free PMC article.
SARS-CoV-2 mucosal neutralising immunity after vaccination.
Carr EJ, Dowgier G, Greenwood D, Herman LS, Hobbs A, Ragno M, Stevenson-Leggett P, Gahir J, Townsley H, Harvey R, Bailey C, Fowler AS, Miah M, Smith C, Miranda M, Bawumia P, Mears HV, Adams L, Hatipoglu E, O'Reilly N, Warchal S, Sawyer C, Ambrose K, Strange A, Kelly G, Beale R, Papineni P, Corrah T, Gilson R, Gamblin S, Kassiotis G, Libri V, Williams B, Swanton C, Gandhi S, Bauer DLV, Wall E, Wu MY. Carr EJ, et al. Among authors: o reilly n. Lancet Infect Dis. 2024 Jan;24(1):e4-e5. doi: 10.1016/S1473-3099(23)00705-3. Epub 2023 Dec 6. Lancet Infect Dis. 2024. PMID: 38070528 No abstract available.
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer.
Wu MY, Shepherd STC, Fendler A, Carr EJ, Au L, Harvey R, Dowgier G, Hobbs A, Herman LS, Ragno M, Adams L, Schmitt AM, Tippu Z, Shum B, Farag S, Rogiers A, O'Reilly N, Bawumia P, Smith C, Carlyle E, Edmonds K, Del Rosario L, Lingard K, Mangwende M, Holt L, Ahmod H, Korteweg J, Foley T, Barber T, Hepworth S, Emslie-Henry A, Caulfield-Lynch N, Byrne F, Deng D, Williams B, Brown M, Caidan S, Gavrielides M, MacRae JI, Kelly G, Peat K, Kelly D, Murra A, Kelly K, O'Flaherty M, Popat S, Yousaf N, Jhanji S, Tatham K, Cunningham D, Van As N, Young K, Furness AJS, Pickering L, Beale R, Swanton C, Gandhi S, Gamblin S, Bauer DLV, Kassiotis G, Howell M, Walker S, Nicholson E, Larkin J, Wall EC, Turajlic S; CAPTURE consortium. Wu MY, et al. Cancer Cell. 2023 May 8;41(5):821-823. doi: 10.1016/j.ccell.2023.04.005. Epub 2023 Apr 13. Cancer Cell. 2023. PMID: 37116490 Free PMC article.
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London.
Bailey C, Sanderson T, Townsley H, Goldman J, Black JRM, Young G, Goldstone R, Fowler AS, Ward S, Jackson DJ, Cubitt L, Dearing V, O'Neil O, Crawford M, Snell D, Finadis M, Edwards A, Perez-Lloret J, Gahir J, Carr EJ, Riddell A, Aitken J, Ambrose K, Sawyer C, O'Reilly N, Caidan S, Wu MY, Walker PA, Hindmarsh S, Howell M, Jordan A, Fleming J, Houlihan C, Nastouli E, Moores R, Hsu D, Papineni P, Corrah T, Gilson R, MacRae J, Hubank M, Van As N, Turajlic S, Beale R, Levi M; Crick COVID-19 Consortium; Barrell S, Williams B, Gamblin S, Nicod J, Gandhi S, Bauer DLV, Wall EC, Swanton C. Bailey C, et al. Lancet. 2023 Jul 1;402(10395):21-24. doi: 10.1016/S0140-6736(23)00917-0. Epub 2023 Jun 19. Lancet. 2023. PMID: 37348521 Free PMC article. No abstract available.
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients.
Carr EJ, Wu M, Harvey R, Wall EC, Kelly G, Hussain S, Howell M, Kassiotis G, Swanton C, Gandhi S, Bauer DL; Haemodialysis COVID-19 consortium; Crick COVID Immunity Pipeline; Billany RE, Graham-Brown MP, Beckett J, Bull K, Shankar S, Henderson S, Motallebzadeh R, Salama AD, Harper L, Mark PB, McAdoo S, Willicombe M, Beale R. Carr EJ, et al. Lancet. 2021 Sep 18;398(10305):1038-1041. doi: 10.1016/S0140-6736(21)01854-7. Epub 2021 Aug 13. Lancet. 2021. PMID: 34391504 Free PMC article. No abstract available.
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay.
Buck MD, Poirier EZ, Cardoso A, Frederico B, Canton J, Barrell S, Beale R, Byrne R, Caidan S, Crawford M, Cubitt L, Gandhi S, Goldstone R, Grant PR, Gulati K, Hindmarsh S, Howell M, Hubank M, Instrell R, Jiang M, Kassiotis G, Lu WT, MacRae JI, Martini I, Miller D, Moore D, Nastouli E, Nicod J, Nightingale L, Olsen J, Oomatia A, O'Reilly N, Rideg A, Song OR, Strange A, Swanton C, Turajlic S, Wu M, Reis e Sousa C; Crick COVID-19 Consortium. Buck MD, et al. Wellcome Open Res. 2021 May 21;6:9. doi: 10.12688/wellcomeopenres.16517.2. eCollection 2021. Wellcome Open Res. 2021. PMID: 34095506 Free PMC article.
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes.
Tut G, Lancaster T, Krutikov M, Sylla P, Bone D, Spalkova E, Bentley C, Amin U, Jadir A, Hulme S, Kaur N, Tut E, Bruton R, Wu MY, Harvey R, Carr EJ; Crick COVID Immunity Pipeline; Beale R, Stirrup O, Shrotri M, Azmi B, Fuller C, Baynton V, Irwin-Singer A, Hayward A, Copas A, Shallcross L, Moss P. Tut G, et al. Nat Aging. 2023 Jan;3(1):93-104. doi: 10.1038/s43587-022-00328-3. Epub 2023 Jan 20. Nat Aging. 2023. PMID: 37118525 Free PMC article.
163 results