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COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history.
Townsley H, Gahir J, Russell TW, Greenwood D, Carr EJ, Dyke M, Adams L, Miah M, Clayton B, Smith C, Miranda M, Mears HV, Bailey C, Black JRM, Fowler AS, Crawford M, Wilkinson K, Hutchinson M, Harvey R, O'Reilly N, Kelly G, Goldstone R, Beale R, Papineni P, Corrah T, Gilson R, Caidan S, Nicod J, Gamblin S, Kassiotis G, Libri V, Williams B, Gandhi S, Kucharski AJ, Swanton C, Bauer DLV, Wall EC. Townsley H, et al. Among authors: mears hv. PLoS One. 2024 Mar 21;19(3):e0294897. doi: 10.1371/journal.pone.0294897. eCollection 2024. PLoS One. 2024. PMID: 38512960 Free PMC article.
Within-host SARS-CoV-2 viral kinetics informed by complex life course exposures reveals different intrinsic properties of Omicron and Delta variants.
Russell TW, Townsley H, Abbott S, Hellewell J, Carr EJ, Chapman L, Pung R, Quilty BJ, Hodgson D, Fowler AS, Adams L, Bailey C, Mears HV, Harvey R, Clayton B, O'Reilly N, Ngai Y, Nicod J, Gamblin S, Williams B, Gandhi S, Swanton C, Beale R, Bauer DL, Wall EC, Kucharski A. Russell TW, et al. Among authors: mears hv. medRxiv [Preprint]. 2023 May 24:2023.05.17.23290105. doi: 10.1101/2023.05.17.23290105. medRxiv. 2023. PMID: 37292842 Free PMC article. Preprint.
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants.
Russell TW, Townsley H, Abbott S, Hellewell J, Carr EJ, Chapman LAC, Pung R, Quilty BJ, Hodgson D, Fowler AS, Adams L, Bailey C, Mears HV, Harvey R, Clayton B, O'Reilly N, Ngai Y, Nicod J, Gamblin S, Williams B, Gandhi S, Swanton C, Beale R, Bauer DLV, Wall EC, Kucharski AJ. Russell TW, et al. Among authors: mears hv. PLoS Biol. 2024 Jan 30;22(1):e3002463. doi: 10.1371/journal.pbio.3002463. eCollection 2024 Jan. PLoS Biol. 2024. PMID: 38289907 Free PMC article.
Three-dose vaccination elicits neutralising antibodies against omicron.
Wu M, Wall EC, Carr EJ, Harvey R, Townsley H, Mears HV, Adams L, Kjaer S, Kelly G, Warchal S, Sawyer C, Kavanagh C, Queval CJ, Ngai Y, Hatipoglu E, Ambrose K, Hindmarsh S, Beale R, Gamblin S, Howell M, Kassiotis G, Libri V, Williams B, Gandhi S, Swanton C, Bauer DL. Wu M, et al. Among authors: mears hv. Lancet. 2022 Feb 19;399(10326):715-717. doi: 10.1016/S0140-6736(22)00092-7. Epub 2022 Jan 19. Lancet. 2022. PMID: 35065005 Free PMC article. No abstract available.
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection.
Carr EJ, Wu MY, Gahir J, Harvey R, Townsley H, Bailey C, Fowler AS, Dowgier G, Hobbs A, Herman L, Ragno M, Miah M, Bawumia P, Smith C, Miranda M, Mears HV, Adams L, Haptipoglu E, O'Reilly N, Warchal S, Sawyer C, Ambrose K, Kelly G, Beale R, Papineni P, Corrah T, Gilson R, Gamblin S, Kassiotis G, Libri V, Williams B, Swanton C, Gandhi S, Lv Bauer D, Wall EC; Crick COVID Serology Consortium. Carr EJ, et al. Among authors: mears hv. Lancet Infect Dis. 2023 Jul;23(7):781-784. doi: 10.1016/S1473-3099(23)00289-X. Epub 2023 Jun 5. Lancet Infect Dis. 2023. PMID: 37290472 Free PMC article. No abstract available.
SARS-CoV-2 mucosal neutralising immunity after vaccination.
Carr EJ, Dowgier G, Greenwood D, Herman LS, Hobbs A, Ragno M, Stevenson-Leggett P, Gahir J, Townsley H, Harvey R, Bailey C, Fowler AS, Miah M, Smith C, Miranda M, Bawumia P, Mears HV, Adams L, Hatipoglu E, O'Reilly N, Warchal S, Sawyer C, Ambrose K, Strange A, Kelly G, Beale R, Papineni P, Corrah T, Gilson R, Gamblin S, Kassiotis G, Libri V, Williams B, Swanton C, Gandhi S, Bauer DLV, Wall E, Wu MY. Carr EJ, et al. Among authors: mears hv. Lancet Infect Dis. 2024 Jan;24(1):e4-e5. doi: 10.1016/S1473-3099(23)00705-3. Epub 2023 Dec 6. Lancet Infect Dis. 2024. PMID: 38070528 No abstract available.
WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed.
Wu MY, Carr EJ, Harvey R, Mears HV, Kjaer S, Townsley H, Hobbs A, Ragno M, Herman LS, Adams L, Gamblin S, Howell M, Beale R, Brown M, Williams B, Gandhi S, Swanton C, Wall EC, Bauer DLV. Wu MY, et al. Among authors: mears hv. Lancet. 2022 Dec 17;400(10369):2193-2196. doi: 10.1016/S0140-6736(22)01938-9. Epub 2022 Oct 6. Lancet. 2022. PMID: 36209762 Free PMC article. No abstract available.
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