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Cell Context is the third axis of synergy for the combination of ATR inhibition and cisplatin in Ewing sarcoma.
Clin Cancer Res. 2024 Mar 20. doi: 10.1158/1078-0432.CCR-23-3063. Online ahead of print.
Clin Cancer Res. 2024.
PMID: 38506712
Targeting the DNA damage response in pediatric malignancies.
Gedminas JM, Laetsch TW.
Gedminas JM, et al.
Expert Rev Anticancer Ther. 2022 Oct;22(10):1099-1113. doi: 10.1080/14737140.2022.2124970. Epub 2022 Sep 23.
Expert Rev Anticancer Ther. 2022.
PMID: 36099180
Review.
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Lurbinectedin Inhibits the EWS-WT1 Transcription Factor in Desmoplastic Small Round Cell Tumor.
Gedminas JM, Kaufman R, Boguslawski EA, Gross AC, Adams M, Beddows I, Kitchen-Goosen SM, Roberts RD, Grohar PJ.
Gedminas JM, et al.
Mol Cancer Ther. 2022 Aug 2;21(8):1296-1305. doi: 10.1158/1535-7163.MCT-21-1003.
Mol Cancer Ther. 2022.
PMID: 35657345
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Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor.
Gedminas JM, Chasse MH, McBrairty M, Beddows I, Kitchen-Goosen SM, Grohar PJ.
Gedminas JM, et al.
Oncogenesis. 2020 Apr 28;9(4):41. doi: 10.1038/s41389-020-0224-1.
Oncogenesis. 2020.
PMID: 32345977
Free PMC article.
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Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.
Harlow ML, Chasse MH, Boguslawski EA, Sorensen KM, Gedminas JM, Kitchen-Goosen SM, Rothbart SB, Taslim C, Lessnick SL, Peck AS, Madaj ZB, Bowman MJ, Grohar PJ.
Harlow ML, et al. Among authors: gedminas jm.
Clin Cancer Res. 2019 Jun 1;25(11):3417-3429. doi: 10.1158/1078-0432.CCR-18-3511. Epub 2019 Feb 5.
Clin Cancer Res. 2019.
PMID: 30723142
Free PMC article.
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