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T cell specific deletion of Casitas B lineage lymphoma-b reduces atherosclerosis, but increases plaque T cell infiltration and systemic T cell activation.
Vos WG, van Os BW, den Toom M, Beckers L, van Roomen CPAA, van Tiel CM, Mohapatra BC, Band H, Nitz K, Weber C, Atzler D, de Winther MPJ, Bosmans LA, Lutgens E, Seijkens TTP. Vos WG, et al. Among authors: van roomen cpaa. Front Immunol. 2024 Mar 4;15:1297893. doi: 10.3389/fimmu.2024.1297893. eCollection 2024. Front Immunol. 2024. PMID: 38504977 Free PMC article.
DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Willemsen L, Prange KHM, Neele AE, van Roomen CPAA, Gijbels M, Griffith GR, Toom MD, Beckers L, Siebeler R, Spann NJ, Chen HJ, Bosmans LA, Gorbatenko A, van Wouw S, Zelcer N, Jacobs H, van Leeuwen F, de Winther MPJ. Willemsen L, et al. Among authors: van roomen cpaa. Cell Rep. 2022 Nov 22;41(8):111703. doi: 10.1016/j.celrep.2022.111703. Cell Rep. 2022. PMID: 36417856 Free article.
High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages.
Hoepel W, Chen HJ, Geyer CE, Allahverdiyeva S, Manz XD, de Taeye SW, Aman J, Mes L, Steenhuis M, Griffith GR, Bonta PI, Brouwer PJM, Caniels TG, van der Straten K, Golebski K, Jonkers RE, Larsen MD, Linty F, Nouta J, van Roomen CPAA, van Baarle FEHP, van Drunen CM, Wolbink G, Vlaar APJ, de Bree GJ, Sanders RW, Willemsen L, Neele AE, van de Beek D, Rispens T, Wuhrer M, Bogaard HJ, van Gils MJ, Vidarsson G, de Winther M, den Dunnen J. Hoepel W, et al. Among authors: van roomen cpaa. Sci Transl Med. 2021 Jun 2;13(596):eabf8654. doi: 10.1126/scitranslmed.abf8654. Epub 2021 May 11. Sci Transl Med. 2021. PMID: 33979301 Free PMC article.
Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.
Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen CPAA, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ. Willemsen L, et al. Among authors: van roomen cpaa. BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000751. doi: 10.1136/bmjdrc-2019-000751. eCollection 2019. BMJ Open Diabetes Res Care. 2019. PMID: 31798899 Free PMC article.
Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy.
Beldman TJ, Malinova TS, Desclos E, Grootemaat AE, Misiak ALS, van der Velden S, van Roomen CPAA, Beckers L, van Veen HA, Krawczyk PM, Hoebe RA, Sluimer JC, Neele AE, de Winther MPJ, van der Wel NN, Lutgens E, Mulder WJM, Huveneers S, Kluza E. Beldman TJ, et al. Among authors: van roomen cpaa. ACS Nano. 2019 Dec 24;13(12):13759-13774. doi: 10.1021/acsnano.8b08875. Epub 2019 Jul 10. ACS Nano. 2019. PMID: 31268670 Free PMC article.
Stabilization of Glucocerebrosidase by Active Site Occupancy.
Ben Bdira F, Kallemeijn WW, Oussoren SV, Scheij S, Bleijlevens B, Florea BI, van Roomen CPAA, Ottenhoff R, van Kooten MJFM, Walvoort MTC, Witte MD, Boot RG, Ubbink M, Overkleeft HS, Aerts JMFG. Ben Bdira F, et al. Among authors: van roomen cpaa. ACS Chem Biol. 2017 Jul 21;12(7):1830-1841. doi: 10.1021/acschembio.7b00276. Epub 2017 May 22. ACS Chem Biol. 2017. PMID: 28485919 Free PMC article.
A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.
Marques AR, Willems LI, Herrera Moro D, Florea BI, Scheij S, Ottenhoff R, van Roomen CP, Verhoek M, Nelson JK, Kallemeijn WW, Biela-Banas A, Martin OR, Cachón-González MB, Kim NN, Cox TM, Boot RG, Overkleeft HS, Aerts JM. Marques AR, et al. Chembiochem. 2017 Feb 16;18(4):402-412. doi: 10.1002/cbic.201600561. Epub 2017 Jan 31. Chembiochem. 2017. PMID: 28000364 Free article.
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