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Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing.
Appelbaum J, Price AE, Oda K, Zhang J, Leung WH, Tampella G, Xia D, So PP, Hilton SK, Evandy C, Sarkar S, Martin U, Krostag AR, Leonardi M, Zak DE, Logan R, Lewis P, Franke-Welch S, Ngwenyama N, Fitzgerald M, Tulberg N, Rawlings-Rhea S, Gardner RA, Jones K, Sanabria A, Crago W, Timmer J, Hollands A, Eckelman B, Bilic S, Woodworth J, Lamble A, Gregory PD, Jarjour J, Pogson M, Gustafson JA, Astrakhan A, Jensen MC. Appelbaum J, et al. Among authors: astrakhan a. J Clin Invest. 2024 Mar 19;134(9):e162593. doi: 10.1172/JCI162593. J Clin Invest. 2024. PMID: 38502193 Free PMC article. Clinical Trial.
Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.
Hale M, Lee B, Honaker Y, Leung WH, Grier AE, Jacobs HM, Sommer K, Sahni J, Jackson SW, Scharenberg AM, Astrakhan A, Rawlings DJ. Hale M, et al. Among authors: astrakhan a. Mol Ther Methods Clin Dev. 2017 Jan 10;4:192-203. doi: 10.1016/j.omtm.2016.12.008. eCollection 2017 Mar 17. Mol Ther Methods Clin Dev. 2017. PMID: 28345004 Free PMC article.
Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.
Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ. Sather BD, et al. Among authors: astrakhan a. Sci Transl Med. 2015 Sep 30;7(307):307ra156. doi: 10.1126/scitranslmed.aac5530. Sci Transl Med. 2015. PMID: 26424571 Free PMC article.
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.
Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM. Boissel S, et al. Among authors: astrakhan a. Nucleic Acids Res. 2014 Feb;42(4):2591-601. doi: 10.1093/nar/gkt1224. Epub 2013 Nov 26. Nucleic Acids Res. 2014. PMID: 24285304 Free PMC article.
14 results