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Experimental evidence that maleic acid markedly compromises glutamate oxidation through inhibition of glutamate dehydrogenase and α-ketoglutarate dehydrogenase activities in kidney of developing rats.
Roginski AC, Cecatto C, Wajner SM, Camera FD, Castilho RF, Wajner M, Amaral AU. Roginski AC, et al. Among authors: amaral au. Mol Cell Biochem. 2019 Aug;458(1-2):99-112. doi: 10.1007/s11010-019-03534-7. Epub 2019 Apr 29. Mol Cell Biochem. 2019. PMID: 31032535
In Vivo Intracerebral Administration of α-Ketoisocaproic Acid to Neonate Rats Disrupts Brain Redox Homeostasis and Promotes Neuronal Death, Glial Reactivity, and Myelination Injury.
Zemniaçak ÂB, Ribeiro RT, Pinheiro CV, de Azevedo Cunha S, Tavares TQ, Castro ET, Leipnitz G, Wajner M, Amaral AU. Zemniaçak ÂB, et al. Among authors: amaral au. Mol Neurobiol. 2024 May;61(5):2496-2513. doi: 10.1007/s12035-023-03718-9. Epub 2023 Nov 1. Mol Neurobiol. 2024. PMID: 37910283
Disruption of brain redox homeostasis in glutaryl-CoA dehydrogenase deficient mice treated with high dietary lysine supplementation.
Seminotti B, Amaral AU, da Rosa MS, Fernandes CG, Leipnitz G, Olivera-Bravo S, Barbeito L, Ribeiro CA, de Souza DO, Woontner M, Goodman SI, Koeller DM, Wajner M. Seminotti B, et al. Among authors: amaral au. Mol Genet Metab. 2013 Jan;108(1):30-9. doi: 10.1016/j.ymgme.2012.11.001. Epub 2012 Nov 9. Mol Genet Metab. 2013. PMID: 23218171
Oxidative Stress, Disrupted Energy Metabolism, and Altered Signaling Pathways in Glutaryl-CoA Dehydrogenase Knockout Mice: Potential Implications of Quinolinic Acid Toxicity in the Neuropathology of Glutaric Acidemia Type I.
Seminotti B, Amaral AU, Ribeiro RT, Rodrigues MDN, Colín-González AL, Leipnitz G, Santamaría A, Wajner M. Seminotti B, et al. Among authors: amaral au. Mol Neurobiol. 2016 Nov;53(9):6459-6475. doi: 10.1007/s12035-015-9548-9. Epub 2015 Nov 25. Mol Neurobiol. 2016. PMID: 26607633
cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca(2+) homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency.
Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KDS, Ribeiro RT, Wajner M. Amaral AU, et al. Biochim Biophys Acta. 2016 Sep;1857(9):1363-1372. doi: 10.1016/j.bbabio.2016.05.007. Epub 2016 May 27. Biochim Biophys Acta. 2016. PMID: 27240720 Free article.
87 results