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Physics-driven structural docking and protein language models accelerate antibody screening and design for broad-spectrum antiviral therapy.
Almubarak HF, Tan W, Hoffmann AD, Wei J, El-Shennawy L, Squires JR, Sun Y, Dashzeveg NK, Simonton B, Jia Y, Iyer R, Xu Y, Nicolaescu V, Elli D, Randall GC, Schipma MJ, Swaminathan S, Ison MG, Liu H, Fang D, Shen Y. Almubarak HF, et al. Among authors: schipma mj. bioRxiv [Preprint]. 2024 Mar 4:2024.03.01.582176. doi: 10.1101/2024.03.01.582176. bioRxiv. 2024. PMID: 38496411 Free PMC article. Preprint.
Unique molecular signatures sustained in circulating monocytes and regulatory T cells in Convalescent COVID-19 patients.
Hoffmann AD, Weinberg SE, Swaminathan S, Chaudhuri S, Mubarak HF, Schipma MJ, Mao C, Wang X, El-Shennawy L, Dashzeveg NK, Wei J, Mehl PJ, Shihadah LJ, Wai CM, Ostiguin C, Jia Y, D'Amico P, Wang NR, Luo Y, Demonbreun AR, Ison MG, Liu H, Fang D. Hoffmann AD, et al. Among authors: schipma mj. bioRxiv [Preprint]. 2022 Mar 28:2022.03.26.485922. doi: 10.1101/2022.03.26.485922. bioRxiv. 2022. PMID: 35378753 Free PMC article. Updated. Preprint.
Post-ischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis.
Tiwari R, Sharma R, Rajendran G, Borkowski GS, An SY, Schonfeld M, O'Sullivan J, Schipma MJ, Zhou Y, Courbon G, David V, Quaggin SE, Thorp E, Chandel NS, Kapitsinou PP. Tiwari R, et al. Among authors: schipma mj. bioRxiv [Preprint]. 2023 Oct 3:2023.10.03.560700. doi: 10.1101/2023.10.03.560700. bioRxiv. 2023. PMID: 37873349 Free PMC article. Preprint.
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Bosch ME, Dodiya HB, Michalkiewicz J, Lee C, Shaik SM, Weigle IQ, Zhang C, Osborn J, Nambiar A, Patel P, Parhizkar S, Zhang X, Laury ML, Mondal P, Gomm A, Schipma MJ, Mallah D, Butovsky O, Chang EB, Tanzi RE, Gilbert JA, Holtzman DM, Sisodia SS. Bosch ME, et al. Among authors: schipma mj. Mol Neurodegener. 2024 Feb 17;19(1):18. doi: 10.1186/s13024-023-00700-w. Mol Neurodegener. 2024. PMID: 38365827 Free PMC article.
Tissue-specific reprogramming leads to angiogenic neutrophil specialization and tumor vascularization in colorectal cancer.
Bui TM, Yalom LK, Ning E, Urbanczyk JM, Ren X, Herrnreiter CJ, Disario JA, Wray B, Schipma MJ, Velichko YS, Sullivan DP, Abe K, Lauberth SM, Yang GY, Dulai PS, Hanauer SB, Sumagin R. Bui TM, et al. Among authors: schipma mj. J Clin Invest. 2024 Apr 1;134(7):e174545. doi: 10.1172/JCI174545. J Clin Invest. 2024. PMID: 38329810 Free PMC article.
Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis.
Takata N, Miska JM, Morgan MA, Patel P, Billingham LK, Joshi N, Schipma MJ, Dumar ZJ, Joshi NR, Misharin AV, Embry RB, Fiore L, Gao P, Diebold LP, McElroy GS, Shilatifard A, Chandel NS, Oliver G. Takata N, et al. Among authors: schipma mj. Nat Commun. 2023 Jul 14;14(1):4129. doi: 10.1038/s41467-023-39672-2. Nat Commun. 2023. PMID: 37452018 Free PMC article.
Unique molecular signatures sustained in circulating monocytes and regulatory T cells in convalescent COVID-19 patients.
Hoffmann AD, Weinberg SE, Swaminathan S, Chaudhuri S, Almubarak HF, Schipma MJ, Mao C, Wang X, El-Shennawy L, Dashzeveg NK, Wei J, Mehl PJ, Shihadah LJ, Wai CM, Ostiguin C, Jia Y, D'Amico P, Wang NR, Luo Y, Demonbreun AR, Ison MG, Liu H, Fang D. Hoffmann AD, et al. Among authors: schipma mj. Clin Immunol. 2023 Jul;252:109634. doi: 10.1016/j.clim.2023.109634. Epub 2023 May 5. Clin Immunol. 2023. PMID: 37150240 Free PMC article.
Checkpoint kinase 1/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade.
Dmello C, Zhao J, Chen L, Gould A, Castro B, Arrieta VA, Zhang DY, Kim KS, Kanojia D, Zhang P, Miska J, Yeeravalli R, Habashy K, Saganty R, Kang SJ, Fares J, Liu C, Dunn G, Bartom E, Schipma MJ, Hsu PD, Alghamri MS, Lesniak MS, Heimberger AB, Rabadan R, Lee-Chang C, Sonabend AM. Dmello C, et al. Among authors: schipma mj. Nat Commun. 2023 Mar 22;14(1):1566. doi: 10.1038/s41467-023-36878-2. Nat Commun. 2023. PMID: 36949040 Free PMC article.
Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt.
Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M, Meier JL, Hummel M. Forte E, et al. Among authors: schipma mj. Microbiol Spectr. 2023 Feb 14;11(1):e0314422. doi: 10.1128/spectrum.03144-22. Epub 2023 Jan 16. Microbiol Spectr. 2023. PMID: 36645269 Free PMC article.
50 results