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The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity.
Lim J, Rodriguez R, Williams K, Silva J, Gutierrez AG, Tyler P, Baharom F, Sun T, Lin E, Martin S, Kayser BD, Johnston RJ, Mellman I, Delamarre L, West NR, Müller S, Qu Y, Heger K. Lim J, et al. Among authors: williams k. Cancer Immunol Res. 2024 Mar 18. doi: 10.1158/2326-6066.CIR-23-1078. Online ahead of print. Cancer Immunol Res. 2024. PMID: 38489753
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, Capietto AH, Cubas R, Modrusan Z, Sandoval W, Ziai J, Gould SE, Fu W, Wang Y, Koerber JT, Sanjabi S, Mellman I, Turley SJ, Müller S. Castiglioni A, et al. Among authors: williams k. Nat Commun. 2023 Aug 5;14(1):4703. doi: 10.1038/s41467-023-40398-4. Nat Commun. 2023. PMID: 37543621 Free PMC article.
Durable lymph-node expansion is associated with the efficacy of therapeutic vaccination.
Najibi AJ, Lane RS, Sobral MC, Bovone G, Kang S, Freedman BR, Gutierrez Estupinan J, Elosegui-Artola A, Tringides CM, Dellacherie MO, Williams K, Ijaz H, Müller S, Turley SJ, Mooney DJ. Najibi AJ, et al. Among authors: williams k. Nat Biomed Eng. 2024 May 6. doi: 10.1038/s41551-024-01209-3. Online ahead of print. Nat Biomed Eng. 2024. PMID: 38710838
Drone-facilitated real-time video-guided feedback helps to improve the quality of lay bystander basic life support. A randomized controlled simulation trial.
Kienbacher CL, Schreiber W, Herkner H, Holzhacker C, Chwojka CC, Tscherny K, Egger A, Fuhrmann V, Niederer M, Neymayer M, Bernert L, Gamsjäger A, Grünbeck I, Heitger MB, Saleh L, Schmidt S, Schönecker S, Wirth D, Williams KA, Roth D. Kienbacher CL, et al. Among authors: williams ka. Prehosp Emerg Care. 2024 May 22:1-12. doi: 10.1080/10903127.2024.2351970. Online ahead of print. Prehosp Emerg Care. 2024. PMID: 38776259
Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.
Turner GR, Hewan P, Wearn A, van Dooren R, Wyatt L, Leppert IR, Baracchini G, Hughes C, Williams KM, Sylvain E, Tremblay-Mercier J, Poirier J, Villeneuve S, Tardif C, Spreng RN; PREVENT-AD Research Group. Turner GR, et al. Among authors: williams km. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2322617121. doi: 10.1073/pnas.2322617121. Epub 2024 May 21. Proc Natl Acad Sci U S A. 2024. PMID: 38771873 Free article.
7,709 results