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The exonuclease TREX1 constitutes an innate immune checkpoint limiting cGAS/STING-mediated antitumor immunity.
Lim J, Rodriguez R, Williams K, Silva J, Gutierrez AG, Tyler P, Baharom F, Sun T, Lin E, Martin S, Kayser BD, Johnston RJ, Mellman I, Delamarre L, West NR, Müller S, Qu Y, Heger K. Lim J, et al. Among authors: mellman i. Cancer Immunol Res. 2024 Mar 18. doi: 10.1158/2326-6066.CIR-23-1078. Online ahead of print. Cancer Immunol Res. 2024. PMID: 38489753
Harnessing dendritic cells for immunotherapy.
Delamarre L, Mellman I. Delamarre L, et al. Among authors: mellman i. Semin Immunol. 2011 Feb;23(1):2-11. doi: 10.1016/j.smim.2011.02.001. Epub 2011 Mar 5. Semin Immunol. 2011. PMID: 21377379 Review.
Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8+ T Cells in Murine Syngeneic Tumor Models.
Xiong H, Mittman S, Rodriguez R, Pacheco-Sanchez P, Moskalenko M, Yang Y, Elstrott J, Ritter AT, Müller S, Nickles D, Arenzana TL, Capietto AH, Delamarre L, Modrusan Z, Rutz S, Mellman I, Cubas R. Xiong H, et al. Among authors: mellman i. Cancer Immunol Res. 2019 Jun;7(6):963-976. doi: 10.1158/2326-6066.CIR-18-0750. Epub 2019 May 7. Cancer Immunol Res. 2019. PMID: 31064777
Cancer immunotherapy. Neo approaches to cancer vaccines.
Delamarre L, Mellman I, Yadav M. Delamarre L, et al. Among authors: mellman i. Science. 2015 May 15;348(6236):760-1. doi: 10.1126/science.aab3465. Science. 2015. PMID: 25977539 No abstract available.
IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.
Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre L, Mellman I. Tahtinen S, et al. Among authors: mellman i. Nat Immunol. 2022 Apr;23(4):532-542. doi: 10.1038/s41590-022-01160-y. Epub 2022 Mar 24. Nat Immunol. 2022. PMID: 35332327
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.
Castiglioni A, Yang Y, Williams K, Gogineni A, Lane RS, Wang AW, Shyer JA, Zhang Z, Mittman S, Gutierrez A, Astarita JL, Thai M, Hung J, Yang YA, Pourmohamad T, Himmels P, De Simone M, Elstrott J, Capietto AH, Cubas R, Modrusan Z, Sandoval W, Ziai J, Gould SE, Fu W, Wang Y, Koerber JT, Sanjabi S, Mellman I, Turley SJ, Müller S. Castiglioni A, et al. Among authors: mellman i. Nat Commun. 2023 Aug 5;14(1):4703. doi: 10.1038/s41467-023-40398-4. Nat Commun. 2023. PMID: 37543621 Free PMC article.
Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells.
Katakam AK, Brightbill H, Franci C, Kung C, Nunez V, Jones C 3rd, Peng I, Jeet S, Wu LC, Mellman I, Delamarre L, Austin CD. Katakam AK, et al. Among authors: mellman i. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14664-9. doi: 10.1073/pnas.1520627112. Epub 2015 Nov 11. Proc Natl Acad Sci U S A. 2015. PMID: 26561586 Free PMC article.
308 results