Gao Z - Search Results

1

Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants.

Wang Z, Zhang H, Gao Z, Sang Z, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Wang Z, et al. Among authors: gao z. Acta Pharm Sin B. 2024 Mar;14(3):1257-1282. doi: 10.1016/j.apsb.2023.11.023. Epub 2023 Nov 24. Acta Pharm Sin B. 2024. PMID: 38486991 Free PMC article.

2

Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity.

Ju H, Hou L, Zhao F, Zhang Y, Jia R, Guizzo L, Bonomini A, Zhang J, Gao Z, Liang R, Bertagnin C, Kong X, Ma X, Kang D, Loregian A, Huang B, Liu X, Zhan P. Ju H, et al. Among authors: gao z. J Med Chem. 2022 Sep 8;65(17):11550-11573. doi: 10.1021/acs.jmedchem.1c01970. Epub 2022 Aug 8. J Med Chem. 2022. PMID: 35939763

3

Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein.

Jiang X, Sharma PP, Rathi B, Ji X, Hu L, Gao Z, Kang D, Wang Z, Xie M, Xu S, Zhang X, De Clercq E, Cocklin S, Pannecouque C, Dick A, Liu X, Zhan P. Jiang X, et al. Among authors: gao z. J Med Virol. 2022 Dec;94(12):5975-5986. doi: 10.1002/jmv.28064. Epub 2022 Aug 18. J Med Virol. 2022. PMID: 35949003 Free PMC article.

4

Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778.

Ji X, Jiang X, Kobayashi C, Ren Y, Hu L, Gao Z, Kang D, Jia R, Zhang X, Zhao S, Watashi K, Liu X, Zhan P. Ji X, et al. Among authors: gao z. Molecules. 2022 Sep 14;27(18):5987. doi: 10.3390/molecules27185987. Molecules. 2022. PMID: 36144715 Free PMC article.

5

Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction.

Ji X, Li J, Sharma PP, Jiang X, Rathi B, Gao Z, Hu L, Kang D, De Clercq E, Cocklin S, Liu C, Pannecouque C, Dick A, Liu X, Zhan P. Ji X, et al. Among authors: gao z. Molecules. 2022 Sep 14;27(18):5995. doi: 10.3390/molecules27185995. Molecules. 2022. PMID: 36144727 Free PMC article.

6

Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant.

Jia R, Zhang J, Zhang J, Bertagnin C, Bonomini A, Guizzo L, Gao Z, Ji X, Li Z, Liu C, Ju H, Ma X, Loregian A, Huang B, Zhan P, Liu X. Jia R, et al. Among authors: gao z. Molecules. 2022 Sep 29;27(19):6426. doi: 10.3390/molecules27196426. Molecules. 2022. PMID: 36234966 Free PMC article.

7

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors.

Jiang X, Huang B, Rumrill S, Pople D, Zalloum WA, Kang D, Zhao F, Ji X, Gao Z, Hu L, Wang Z, Xie M, De Clercq E, Ruiz FX, Arnold E, Pannecouque C, Liu X, Zhan P. Jiang X, et al. Among authors: gao z. Commun Chem. 2023 Apr 29;6(1):83. doi: 10.1038/s42004-023-00888-4. Commun Chem. 2023. PMID: 37120482 Free PMC article.

8

Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles.

Jiang X, Huang B, Zalloum WA, Chen CH, Ji X, Gao Z, Dai J, Xie M, Kang D, De Clercq E, Pannecouque C, Liu X, Zhan P. Jiang X, et al. Among authors: gao z. Eur J Med Chem. 2023 Oct 5;258:115605. doi: 10.1016/j.ejmech.2023.115605. Epub 2023 Jun 28. Eur J Med Chem. 2023. PMID: 37393790

9

Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability.

Shi X, Zhao T, Wang S, Xu S, Liao H, Gao S, Gao Z, Zhang J, Qi D, Zhang Z, Zheng F, Wang Y, Wang Z, Yang M, Yang Q, Yi F, Pang J, Liu X, Zhan P. Shi X, et al. Among authors: gao s, gao z. J Med Chem. 2024 Mar 28;67(6):5032-5052. doi: 10.1021/acs.jmedchem.4c00136. Epub 2024 Mar 14. J Med Chem. 2024. PMID: 38482820

10

Discovery of low-molecular-weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability.

Jiang X, Gao Z, Sharma PP, Kumar S, Rathi B, Ji X, Dai J, Xie M, Dong G, Xu S, De Clercq E, Pannecouque C, Dick A, Zhan P, Liu X. Jiang X, et al. Among authors: gao z. J Med Virol. 2024 Apr;96(4):e29594. doi: 10.1002/jmv.29594. J Med Virol. 2024. PMID: 38576317

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