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Silibinin is a suppressor of the metastasis-promoting transcription factor ID3.
Verdura S, Encinar JA, Gratchev A, Llop-Hernández À, López J, Serrano-Hervás E, Teixidor E, López-Bonet E, Martin-Castillo B, Micol V, Bosch-Barrera J, Cuyàs E, Menendez JA. Verdura S, et al. Phytomedicine. 2024 Jun;128:155493. doi: 10.1016/j.phymed.2024.155493. Epub 2024 Mar 6. Phytomedicine. 2024. PMID: 38484626 Free article.
Silibinin is a direct inhibitor of STAT3.
Verdura S, Cuyàs E, Llorach-Parés L, Pérez-Sánchez A, Micol V, Nonell-Canals A, Joven J, Valiente M, Sánchez-Martínez M, Bosch-Barrera J, Menendez JA. Verdura S, et al. Food Chem Toxicol. 2018 Jun;116(Pt B):161-172. doi: 10.1016/j.fct.2018.04.028. Epub 2018 Apr 14. Food Chem Toxicol. 2018. PMID: 29660364
The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes.
Cuyàs E, Gumuzio J, Verdura S, Brunet J, Bosch-Barrera J, Martin-Castillo B, Alarcón T, Encinar JA, Martin ÁG, Menendez JA. Cuyàs E, et al. Among authors: verdura s. Aging (Albany NY). 2020 Mar 18;12(6):4794-4814. doi: 10.18632/aging.102887. Epub 2020 Mar 18. Aging (Albany NY). 2020. PMID: 32191225 Free PMC article.
Silibinin Suppresses Tumor Cell-Intrinsic Resistance to Nintedanib and Enhances Its Clinical Activity in Lung Cancer.
Bosch-Barrera J, Verdura S, Ruffinelli JC, Carcereny E, Sais E, Cuyàs E, Palmero R, Lopez-Bonet E, Hernández-Martínez A, Oliveras G, Buxó M, Izquierdo A, Morán T, Nadal E, Menendez JA. Bosch-Barrera J, et al. Among authors: verdura s. Cancers (Basel). 2021 Aug 19;13(16):4168. doi: 10.3390/cancers13164168. Cancers (Basel). 2021. PMID: 34439322 Free PMC article.
Clinical Management of COVID-19 in Cancer Patients with the STAT3 Inhibitor Silibinin.
Bosch-Barrera J, Roqué A, Teixidor E, Carmona-Garcia MC, Arbusà A, Brunet J, Martin-Castillo B, Cuyàs E, Verdura S, Menendez JA. Bosch-Barrera J, et al. Among authors: verdura s. Pharmaceuticals (Basel). 2021 Dec 24;15(1):19. doi: 10.3390/ph15010019. Pharmaceuticals (Basel). 2021. PMID: 35056076 Free PMC article.
52 results