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Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure.
Spreafico A, Couselo EM, Irmisch A, Bessa J, Au-Yeung G, Bechter O, Svane IM, Sanmamed MF, Gambardella V, McKean M, Callahan M, Dummer R, Klein C, Umaña P, Justies N, Heil F, Fahrni L, Opolka-Hoffmann E, Waldhauer I, Bleul C, Staack RF, Karanikas V, Fowler S. Spreafico A, et al. Among authors: opolka hoffmann e. Front Oncol. 2024 Mar 21;14:1346502. doi: 10.3389/fonc.2024.1346502. eCollection 2024. Front Oncol. 2024. PMID: 38577337 Free PMC article.
Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice.
Egli J, Heiler S, Weber F, Steiner G, Schwandt T, Bray-French K, Klein C, Fenn S, Lotz GP, Opolka-Hoffmann E, Kraft TE, Petersen L, Moser R, DeGeer J, Siegel M, Finke D, Bessa J, Iglesias A. Egli J, et al. Among authors: opolka hoffmann e. MAbs. 2022 Jan-Dec;14(1):2143009. doi: 10.1080/19420862.2022.2143009. MAbs. 2022. PMID: 36394299 Free PMC article.