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Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure.
Front Oncol. 2024 Mar 21;14:1346502. doi: 10.3389/fonc.2024.1346502. eCollection 2024.
Front Oncol. 2024.
PMID: 38577337
Free PMC article.
Biodistribution of Drug/ADA Complexes: The Impact of Immune Complex Formation on Antibody Distribution.
Opolka-Hoffmann E, Edelmann MR, Otteneder MB, Hauri S, Jordan G, Schrag P, Lechmann M, Winter G, Staack RF.
Opolka-Hoffmann E, et al.
AAPS J. 2024 Mar 13;26(2):33. doi: 10.1208/s12248-024-00899-6.
AAPS J. 2024.
PMID: 38478197
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High ionic strength dissociation assay reduces dimeric target interference in immunogenicity testing.
Pöhler A, Jany C, Butzer J, Bach T, Opolka-Hoffmann E, Staack RF, Jordan G.
Pöhler A, et al. Among authors: opolka hoffmann e.
Bioanalysis. 2023 Jul;15(14):823-832. doi: 10.4155/bio-2023-0082. Epub 2023 Jun 16.
Bioanalysis. 2023.
PMID: 37326333
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Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice.
Egli J, Heiler S, Weber F, Steiner G, Schwandt T, Bray-French K, Klein C, Fenn S, Lotz GP, Opolka-Hoffmann E, Kraft TE, Petersen L, Moser R, DeGeer J, Siegel M, Finke D, Bessa J, Iglesias A.
Egli J, et al. Among authors: opolka hoffmann e.
MAbs. 2022 Jan-Dec;14(1):2143009. doi: 10.1080/19420862.2022.2143009.
MAbs. 2022.
PMID: 36394299
Free PMC article.
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The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance.
Opolka-Hoffmann E, Jordan G, Otteneder M, Kieferle R, Lechmann M, Winter G, Staack RF.
Opolka-Hoffmann E, et al.
MAbs. 2021 Jan-Dec;13(1):1995929. doi: 10.1080/19420862.2021.1995929.
MAbs. 2021.
PMID: 34763611
Free PMC article.
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