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The prostaglandin E2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity.
Neuman JC, Reuter A, Carbajal KA, Schaid MD, Kelly G, Connors K, Kaiser C, Krause J, Hurley LD, Olvera A, Davis DB, Wisinski JA, Gannon M, Kimple ME. Neuman JC, et al. Among authors: gannon m. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E567-E576. doi: 10.1152/ajpendo.00061.2023. Epub 2024 Mar 13. Am J Physiol Endocrinol Metab. 2024. PMID: 38477664
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage.
Bosma KJ, Andrei SR, Katz LS, Smith AA, Dunn JC, Ricciardi VF, Ramirez MA, Baumel-Alterzon S, Pace WA, Carroll DT, Overway EM, Wolf EM, Kimple ME, Sheng Q, Scott DK, Breyer RM, Gannon M. Bosma KJ, et al. Among authors: gannon m. Mol Metab. 2021 Dec;54:101347. doi: 10.1016/j.molmet.2021.101347. Epub 2021 Oct 6. Mol Metab. 2021. PMID: 34626853 Free PMC article.
The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.
Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM. Ceddia RP, et al. Among authors: gannon m. Endocrinology. 2016 Jan;157(1):220-32. doi: 10.1210/en.2015-1693. Epub 2015 Oct 20. Endocrinology. 2016. PMID: 26485614 Free PMC article.
Maternal Western-style diet in nonhuman primates leads to offspring islet adaptations including altered gene expression and insulin hypersecretion.
Carroll DT, Elsakr JM, Miller A, Fuhr J, Lindsley SR, Kirigiti M, Takahashi DL, Dean TA, Wesolowski SR, McCurdy CE, Friedman JE, Aagaard KM, Kievit P, Gannon M. Carroll DT, et al. Among authors: gannon m. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E577-E588. doi: 10.1152/ajpendo.00087.2023. Epub 2023 May 3. Am J Physiol Endocrinol Metab. 2023. PMID: 37134140
Increases in bioactive lipids accompany early metabolic changes associated with β-cell expansion in response to short-term high-fat diet.
Seferovic MD, Beamish CA, Mosser RE, Townsend SE, Pappan K, Poitout V, Aagaard KM, Gannon M. Seferovic MD, et al. Among authors: gannon m. Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1251-E1263. doi: 10.1152/ajpendo.00001.2018. Epub 2018 Aug 14. Am J Physiol Endocrinol Metab. 2018. PMID: 30106624 Free PMC article.
533 results