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Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells.
Liu S, Li X, Yang J, Zhu R, Fan Z, Xu X, Feng W, Cui J, Sun J, Liu M. Liu S, et al. Among authors: cui j. FASEB J. 2019 Oct;33(10):11338-11348. doi: 10.1096/fj.201900442R. Epub 2019 Aug 1. FASEB J. 2019. PMID: 31311313 Free PMC article.
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of ProIR and leading to defective insulin signaling that may contribute to beta-cell failure in both MIDY and T2D.-Liu, S., Li, X., Yang, J …
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of P …
Sex Differences in the Prevalence of and Risk Factors for Abnormal Glucose Regulation in Adults Aged 50 Years or Older With Normal Fasting Plasma Glucose Levels.
Zhang X, Liu J, Shao S, Yang Y, Qi D, Wang C, Lin Q, Liu Y, Tu J, Wang J, Ning X, Cui J. Zhang X, et al. Among authors: cui j. Front Endocrinol (Lausanne). 2021 Feb 19;11:531796. doi: 10.3389/fendo.2020.531796. eCollection 2020. Front Endocrinol (Lausanne). 2021. PMID: 33679598 Free PMC article.
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