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A solid beta-sheet structure is formed at the surface of FUS droplets during aging.
Emmanouilidis L, Bartalucci E, Kan Y, Ijavi M, Pérez ME, Afanasyev P, Boehringer D, Zehnder J, Parekh SH, Bonn M, Michaels TCT, Wiegand T, Allain FH. Emmanouilidis L, et al. Among authors: allain fh. Nat Chem Biol. 2024 Mar 11. doi: 10.1038/s41589-024-01573-w. Online ahead of print. Nat Chem Biol. 2024. PMID: 38467846
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation.
Emmanouilidis L, Esteban-Hofer L, Damberger FF, de Vries T, Nguyen CKX, Ibáñez LF, Mergenthal S, Klotzsch E, Yulikov M, Jeschke G, Allain FH. Emmanouilidis L, et al. Among authors: allain fh. Nat Chem Biol. 2021 May;17(5):608-614. doi: 10.1038/s41589-021-00752-3. Epub 2021 Mar 8. Nat Chem Biol. 2021. PMID: 33686294
185 results