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The phosphatidylserine targeting antibody bavituximab plus pembrolizumab in unresectable hepatocellular carcinoma: a phase 2 trial.
Hsiehchen D, Beg MS, Kainthla R, Lohrey J, Kazmi SM, Khosama L, Maxwell MC, Kline H, Katz C, Hassan A, Kubota N, Siglinsky E, Pillai AK, Youssoufian H, Mockbee C, Culm K, Uhlik M, Benjamin L, Brekken RA, Ahn C, Singal AG, Zhu H, Hoshida Y, Yopp AC. Hsiehchen D, et al. Among authors: brekken ra. Nat Commun. 2024 Mar 11;15(1):2178. doi: 10.1038/s41467-024-46542-y. Nat Commun. 2024. PMID: 38467639 Free PMC article. Clinical Trial.
Targeting TAM to Tame Pancreatic Cancer.
von Itzstein MS, Burke MC, Brekken RA, Aguilera TA, Zeh HJ, Beg MS. von Itzstein MS, et al. Among authors: brekken ra. Target Oncol. 2020 Oct;15(5):579-588. doi: 10.1007/s11523-020-00751-9. Target Oncol. 2020. PMID: 32996059 Free PMC article. Review.
Phase 1 trial of bemcentinib (BGB324), a first-in-class, selective AXL inhibitor, with docetaxel in patients with previously treated advanced non-small cell lung cancer.
Bhalla S, Fattah FJ, Ahn C, Williams J, Macchiaroli A, Padro J, Pogue M, Dowell JE, Putnam WC, McCracken N, Micklem D, Brekken RA, Gerber DE. Bhalla S, et al. Among authors: brekken ra. Lung Cancer. 2023 Aug;182:107291. doi: 10.1016/j.lungcan.2023.107291. Epub 2023 Jul 4. Lung Cancer. 2023. PMID: 37423058 Clinical Trial.
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.
Sui L, Wang S, Ganguly D, El Rayes TP, Askeland C, Børretzen A, Sim D, Halvorsen OJ, Knutsvik G, Arnes J, Aziz S, Haukaas S, Foulkes WD, Bielenberg DR, Ziemys A, Mittal V, Brekken RA, Akslen LA, Watnick RS. Sui L, et al. Among authors: brekken ra. Nat Commun. 2022 Dec 27;13(1):7959. doi: 10.1038/s41467-022-35649-9. Nat Commun. 2022. PMID: 36575174 Free PMC article.
223 results