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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
Day JEH, Berdini V, Castro J, Chessari G, Davies TG, Day PJ, St Denis JD, Fujiwara H, Fukaya S, Hamlett CCF, Hearn K, Hiscock SD, Holvey RS, Ito S, Kandola N, Kodama Y, Liebeschuetz JW, Martins V, Matsuo K, Mortenson PN, Muench S, Nakatsuru Y, Ochiiwa H, Palmer N, Peakman T, Price A, Reader M, Rees DC, Rich SJ, Shah A, Shibata Y, Smyth T, Twigg DG, Wallis NG, Williams G, Wilsher NE, Woodhead A, Shimamura T, Johnson CN. Day JEH, et al. Among authors: mortenson pn. J Med Chem. 2024 Mar 28;67(6):4655-4675. doi: 10.1021/acs.jmedchem.3c02118. Epub 2024 Mar 10. J Med Chem. 2024. PMID: 38462716
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.
Murray CW, Berdini V, Buck IM, Carr ME, Cleasby A, Coyle JE, Curry JE, Day JE, Day PJ, Hearn K, Iqbal A, Lee LY, Martins V, Mortenson PN, Munck JM, Page LW, Patel S, Roomans S, Smith K, Tamanini E, Saxty G. Murray CW, et al. Among authors: mortenson pn. ACS Med Chem Lett. 2015 Jun 4;6(7):798-803. doi: 10.1021/acsmedchemlett.5b00143. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191369 Free PMC article.
Fragment-to-Lead Medicinal Chemistry Publications in 2016.
Johnson CN, Erlanson DA, Jahnke W, Mortenson PN, Rees DC. Johnson CN, et al. Among authors: mortenson pn. J Med Chem. 2018 Mar 8;61(5):1774-1784. doi: 10.1021/acs.jmedchem.7b01298. Epub 2017 Oct 31. J Med Chem. 2018. PMID: 29087197 Review.
Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
Cho YS, Angove H, Brain C, Chen CH, Cheng H, Cheng R, Chopra R, Chung K, Congreve M, Dagostin C, Davis DJ, Feltell R, Giraldes J, Hiscock SD, Kim S, Kovats S, Lagu B, Lewry K, Loo A, Lu Y, Luzzio M, Maniara W, McMenamin R, Mortenson PN, Benning R, O'Reilly M, Rees DC, Shen J, Smith T, Wang Y, Williams G, Woolford AJ, Wrona W, Xu M, Yang F, Howard S. Cho YS, et al. Among authors: mortenson pn. ACS Med Chem Lett. 2012 May 17;3(6):445-9. doi: 10.1021/ml200241a. eCollection 2012 Jun 14. ACS Med Chem Lett. 2012. PMID: 24900493 Free PMC article.
Fragment-to-Lead Medicinal Chemistry Publications in 2017.
Mortenson PN, Erlanson DA, de Esch IJP, Jahnke W, Johnson CN. Mortenson PN, et al. J Med Chem. 2019 Apr 25;62(8):3857-3872. doi: 10.1021/acs.jmedchem.8b01472. Epub 2018 Nov 21. J Med Chem. 2019. PMID: 30462504 Review.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
Heightman TD, Callahan JF, Chiarparin E, Coyle JE, Griffiths-Jones C, Lakdawala AS, McMenamin R, Mortenson PN, Norton D, Peakman TM, Rich SJ, Richardson C, Rumsey WL, Sanchez Y, Saxty G, Willems HMG, Wolfe L 3rd, Woolford AJ, Wu Z, Yan H, Kerns JK, Davies TG. Heightman TD, et al. Among authors: mortenson pn. J Med Chem. 2019 May 9;62(9):4683-4702. doi: 10.1021/acs.jmedchem.9b00279. Epub 2019 Apr 25. J Med Chem. 2019. PMID: 30973731
Fragment-to-Lead Medicinal Chemistry Publications in 2018.
Erlanson DA, de Esch IJP, Jahnke W, Johnson CN, Mortenson PN. Erlanson DA, et al. Among authors: mortenson pn. J Med Chem. 2020 May 14;63(9):4430-4444. doi: 10.1021/acs.jmedchem.9b01581. Epub 2020 Jan 22. J Med Chem. 2020. PMID: 31913033
Fragment-to-Lead Medicinal Chemistry Publications in 2019.
Jahnke W, Erlanson DA, de Esch IJP, Johnson CN, Mortenson PN, Ochi Y, Urushima T. Jahnke W, et al. Among authors: mortenson pn. J Med Chem. 2020 Dec 24;63(24):15494-15507. doi: 10.1021/acs.jmedchem.0c01608. Epub 2020 Nov 23. J Med Chem. 2020. PMID: 33226222
27 results