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Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
J Med Chem. 2024 Mar 28;67(6):4655-4675. doi: 10.1021/acs.jmedchem.3c02118. Epub 2024 Mar 10.
J Med Chem. 2024.
PMID: 38462716
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.
Saalau-Bethell SM, Woodhead AJ, Chessari G, Carr MG, Coyle J, Graham B, Hiscock SD, Murray CW, Pathuri P, Rich SJ, Richardson CJ, Williams PA, Jhoti H.
Saalau-Bethell SM, et al. Among authors: hiscock sd.
Nat Chem Biol. 2012 Nov;8(11):920-5. doi: 10.1038/nchembio.1081. Epub 2012 Sep 30.
Nat Chem Biol. 2012.
PMID: 23023261
Free PMC article.
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Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors.
Cho YS, Angove H, Brain C, Chen CH, Cheng H, Cheng R, Chopra R, Chung K, Congreve M, Dagostin C, Davis DJ, Feltell R, Giraldes J, Hiscock SD, Kim S, Kovats S, Lagu B, Lewry K, Loo A, Lu Y, Luzzio M, Maniara W, McMenamin R, Mortenson PN, Benning R, O'Reilly M, Rees DC, Shen J, Smith T, Wang Y, Williams G, Woolford AJ, Wrona W, Xu M, Yang F, Howard S.
Cho YS, et al. Among authors: hiscock sd.
ACS Med Chem Lett. 2012 May 17;3(6):445-9. doi: 10.1021/ml200241a. eCollection 2012 Jun 14.
ACS Med Chem Lett. 2012.
PMID: 24900493
Free PMC article.
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Tandem Diels-Alder/fragmentation approach to the synthesis of eleutherobin.
Winkler JD, Quinn KJ, MacKinnon CH, Hiscock SD, McLaughlin EC.
Winkler JD, et al. Among authors: hiscock sd.
Org Lett. 2003 May 15;5(10):1805-8. doi: 10.1021/ol0345226.
Org Lett. 2003.
PMID: 12735782
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