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Mtb HLA-E-tetramer-sorted CD8+ T cells have a diverse TCR repertoire.
Voogd L, Drittij AMHF, Dingenouts CKE, Franken KLMC, Unen VV, van Meijgaarden KE, Ruibal P, Hagedoorn RS, Leitner JA, Steinberger P, Heemskerk MHM, Davis MM, Scriba TJ, Ottenhoff THM, Joosten SA. Voogd L, et al. Among authors: van meijgaarden ke. iScience. 2024 Feb 15;27(3):109233. doi: 10.1016/j.isci.2024.109233. eCollection 2024 Mar 15. iScience. 2024. PMID: 38439958 Free PMC article.
Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.
van Meijgaarden KE, Haks MC, Caccamo N, Dieli F, Ottenhoff TH, Joosten SA. van Meijgaarden KE, et al. PLoS Pathog. 2015 Mar 24;11(3):e1004671. doi: 10.1371/journal.ppat.1004671. eCollection 2015 Mar. PLoS Pathog. 2015. PMID: 25803478 Free PMC article. Clinical Trial.
Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues.
Ruibal P, Franken KLMC, van Meijgaarden KE, van Loon JJF, van der Steen D, Heemskerk MHM, Ottenhoff THM, Joosten SA. Ruibal P, et al. Among authors: van meijgaarden ke, van loon jjf, van der steen d. J Immunol. 2020 Nov 15;205(10):2861-2872. doi: 10.4049/jimmunol.2000810. Epub 2020 Oct 5. J Immunol. 2020. PMID: 33020145 Free PMC article.
BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways.
Ahmed A, Tripathi H, van Meijgaarden KE, Kumar NC, Adiga V, Rakshit S, Parthiban C, Eveline J S, D'Souza G, Dias M, Ottenhoff THM, Netea MG, Joosten SA, Vyakarnam A. Ahmed A, et al. Among authors: van meijgaarden ke. iScience. 2023 Sep 9;26(10):107889. doi: 10.1016/j.isci.2023.107889. eCollection 2023 Oct 20. iScience. 2023. PMID: 37817935 Free PMC article.
Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.
Joosten SA, van Meijgaarden KE, van Weeren PC, Kazi F, Geluk A, Savage ND, Drijfhout JW, Flower DR, Hanekom WA, Klein MR, Ottenhoff TH. Joosten SA, et al. Among authors: van meijgaarden ke, van weeren pc. PLoS Pathog. 2010 Feb 26;6(2):e1000782. doi: 10.1371/journal.ppat.1000782. PLoS Pathog. 2010. PMID: 20195504 Free PMC article.
107 results