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Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.
Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE. Mok SA, et al. Among authors: zweckstetter m. Nat Struct Mol Biol. 2018 May;25(5):384-393. doi: 10.1038/s41594-018-0057-1. Epub 2018 Apr 30. Nat Struct Mol Biol. 2018. PMID: 29728653 Free PMC article.
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.
Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M. Oroz J, et al. Among authors: zweckstetter m. Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0. Nat Commun. 2018. PMID: 30382094 Free PMC article.
Lysine/RNA-interactions drive and regulate biomolecular condensation.
Ukmar-Godec T, Hutten S, Grieshop MP, Rezaei-Ghaleh N, Cima-Omori MS, Biernat J, Mandelkow E, Söding J, Dormann D, Zweckstetter M. Ukmar-Godec T, et al. Among authors: zweckstetter m. Nat Commun. 2019 Jul 2;10(1):2909. doi: 10.1038/s41467-019-10792-y. Nat Commun. 2019. PMID: 31266957 Free PMC article.
Dynamic Aha1 co-chaperone binding to human Hsp90.
Oroz J, Blair LJ, Zweckstetter M. Oroz J, et al. Among authors: zweckstetter m. Protein Sci. 2019 Sep;28(9):1545-1551. doi: 10.1002/pro.3678. Epub 2019 Aug 6. Protein Sci. 2019. PMID: 31299134 Free PMC article.
287 results