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Glucocorticoid receptor signaling: intricacies and therapeutic opportunities.
Trends Biochem Sci. 2024 May;49(5):431-444. doi: 10.1016/j.tibs.2024.01.012. Epub 2024 Feb 29.
Trends Biochem Sci. 2024.
PMID: 38429217
Free article.
Review.
Selective Modulation of the Human Glucocorticoid Receptor Compromises GR Chromatin Occupancy and Recruitment of p300/CBP and the Mediator Complex.
Van Moortel L, Verhee A, Thommis J, Houtman R, Melchers D, Delhaye L, Van Leene C, Hellemans M, Gevaert K, Eyckerman S, De Bosscher K.
Van Moortel L, et al.
Mol Cell Proteomics. 2024 Mar;23(3):100741. doi: 10.1016/j.mcpro.2024.100741. Epub 2024 Feb 20.
Mol Cell Proteomics. 2024.
PMID: 38387774
Free PMC article.
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The Biologist's Guide to the Glucocorticoid Receptor's Structure.
Deploey N, Van Moortel L, Rogatsky I, Peelman F, De Bosscher K.
Deploey N, et al. Among authors: van moortel l.
Cells. 2023 Jun 15;12(12):1636. doi: 10.3390/cells12121636.
Cells. 2023.
PMID: 37371105
Free PMC article.
Review.
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Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets.
Van Moortel L, Thommis J, Maertens B, Staes A, Clarisse D, De Sutter D, Libert C, Meijer OC, Eyckerman S, Gevaert K, De Bosscher K.
Van Moortel L, et al.
Biomed Pharmacother. 2022 Aug;152:113218. doi: 10.1016/j.biopha.2022.113218. Epub 2022 Jun 13.
Biomed Pharmacother. 2022.
PMID: 35709653
Free article.
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Improved Glucocorticoid Receptor Ligands: Fantastic Beasts, but How to Find Them?
Van Moortel L, Gevaert K, De Bosscher K.
Van Moortel L, et al.
Front Endocrinol (Lausanne). 2020 Sep 24;11:559673. doi: 10.3389/fendo.2020.559673. eCollection 2020.
Front Endocrinol (Lausanne). 2020.
PMID: 33071974
Free PMC article.
Review.
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Compound A influences gene regulation of the Dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment.
Desmet SJ, Bougarne N, Van Moortel L, De Cauwer L, Thommis J, Vuylsteke M, Ratman D, Houtman R, Tavernier J, De Bosscher K.
Desmet SJ, et al. Among authors: van moortel l.
Sci Rep. 2017 Aug 14;7(1):8063. doi: 10.1038/s41598-017-07941-y.
Sci Rep. 2017.
PMID: 28808239
Free PMC article.
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Endothelial Response to Glucocorticoids in Inflammatory Diseases.
Zielińska KA, Van Moortel L, Opdenakker G, De Bosscher K, Van den Steen PE.
Zielińska KA, et al. Among authors: van moortel l.
Front Immunol. 2016 Dec 14;7:592. doi: 10.3389/fimmu.2016.00592. eCollection 2016.
Front Immunol. 2016.
PMID: 28018358
Free PMC article.
Review.
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