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Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models.
Selvarasu K, Singh AK, Iyaswamy A, Gopalkrishnashetty Sreenivasmurthy S, Krishnamoorthi S, Bera AK, Huang JD, Durairajan SSK. Selvarasu K, et al. Among authors: durairajan ssk. Front Mol Biosci. 2022 Oct 25;9:1050768. doi: 10.3389/fmolb.2022.1050768. eCollection 2022. Front Mol Biosci. 2022. PMID: 36387285 Free PMC article.
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition.
Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Senapati S, Malampati S, Zhu Z, Su CF, Liu J, Guan XJ, Tong BC, Cheung KH, Tan JQ, Lu JH, Durairajan SSK, Song JX, Li M. Sreenivasmurthy SG, et al. Among authors: durairajan ssk. Phytomedicine. 2022 Feb;96:153887. doi: 10.1016/j.phymed.2021.153887. Epub 2021 Dec 8. Phytomedicine. 2022. PMID: 34936968
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