Jacobsen MT - Search Results

1

A cysteine-specific solubilizing tag strategy enables efficient chemical protein synthesis of difficult targets.

Li W, Jacobsen MT, Park C, Jung JU, Lin NP, Huang PS, Lal RA, Chou DH. Li W, et al. Among authors: jacobsen mt. Chem Sci. 2024 Jan 19;15(9):3214-3222. doi: 10.1039/d3sc06032b. eCollection 2024 Feb 28. Chem Sci. 2024. PMID: 38425513 Free PMC article.

2

Amine Landscaping to Maximize Protein-Dye Fluorescence and Ultrastable Protein-Ligand Interaction.

Jacobsen MT, Fairhead M, Fogelstrand P, Howarth M. Jacobsen MT, et al. Cell Chem Biol. 2017 Aug 17;24(8):1040-1047.e4. doi: 10.1016/j.chembiol.2017.06.015. Epub 2017 Jul 27. Cell Chem Biol. 2017. PMID: 28757182 Free PMC article.

3

Use of Objective Outcomes Measures to Verify the Effects of ICF-Based Gait Treatment in Huntington's Disease Patient on Globus Pallidus Deep Brain Stimulation: A Case Report.

Capato TTC, Cury RG, Tornai J, Fonoff ET, Guimarães R, Jacobsen MT, Haddad MS, Barbosa ER. Capato TTC, et al. Among authors: jacobsen mt. Front Rehabil Sci. 2022 Apr 14;3:849333. doi: 10.3389/fresc.2022.849333. eCollection 2022. Front Rehabil Sci. 2022. PMID: 36189041 Free PMC article.

4

Improved Handling of Peptide Segments Using Side Chain-Based "Helping Hand" Solubilizing Tools.

Jacobsen MT, Spaltenstein P, Giesler RJ, Chou DH, Kay MS. Jacobsen MT, et al. Methods Mol Biol. 2022;2530:81-107. doi: 10.1007/978-1-0716-2489-0_7. Methods Mol Biol. 2022. PMID: 35761044

5

A glutamic acid-based traceless linker to address challenging chemical protein syntheses.

Giesler RJ, Spaltenstein P, Jacobsen MT, Xu W, Maqueda M, Kay MS. Giesler RJ, et al. Among authors: jacobsen mt. Org Biomol Chem. 2021 Oct 20;19(40):8821-8829. doi: 10.1039/d1ob01611c. Org Biomol Chem. 2021. PMID: 34585207 Free PMC article.

6

Chemical synthesis of Shiga toxin subunit B using a next-generation traceless "helping hand" solubilizing tag.

Fulcher JM, Petersen ME, Giesler RJ, Cruz ZS, Eckert DM, Francis JN, Kawamoto EM, Jacobsen MT, Kay MS. Fulcher JM, et al. Among authors: jacobsen mt. Org Biomol Chem. 2019 Dec 28;17(48):10237-10244. doi: 10.1039/c9ob02012h. Epub 2019 Dec 3. Org Biomol Chem. 2019. PMID: 31793605

7

Aligator: A computational tool for optimizing total chemical synthesis of large proteins.

Jacobsen MT, Erickson PW, Kay MS. Jacobsen MT, et al. Bioorg Med Chem. 2017 Sep 15;25(18):4946-4952. doi: 10.1016/j.bmc.2017.05.061. Epub 2017 Jun 3. Bioorg Med Chem. 2017. PMID: 28651912 Free PMC article. Review.

8

A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis.

Jacobsen MT, Petersen ME, Ye X, Galibert M, Lorimer GH, Aucagne V, Kay MS. Jacobsen MT, et al. J Am Chem Soc. 2016 Sep 14;138(36):11775-82. doi: 10.1021/jacs.6b05719. Epub 2016 Sep 1. J Am Chem Soc. 2016. PMID: 27532670 Free PMC article.

9

Synthesis of tumor necrosis factor α for use as a mirror-image phage display target.

Petersen ME, Jacobsen MT, Kay MS. Petersen ME, et al. Among authors: jacobsen mt. Org Biomol Chem. 2016 Jun 21;14(23):5298-303. doi: 10.1039/c6ob00824k. Epub 2016 May 23. Org Biomol Chem. 2016. PMID: 27211891 Free PMC article.

10

Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.

Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS. Clinton TR, et al. Among authors: jacobsen mt. Protein Sci. 2015 Apr;24(4):446-63. doi: 10.1002/pro.2578. Epub 2014 Oct 31. Protein Sci. 2015. PMID: 25287718 Free PMC article.

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