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Specificity, synergy, and mechanisms of splice-modifying drugs.
Ishigami Y, Wong MS, Martí-Gómez C, Ayaz A, Kooshkbaghi M, Hanson SM, McCandlish DM, Krainer AR, Kinney JB. Ishigami Y, et al. Among authors: mccandlish dm. Nat Commun. 2024 Feb 29;15(1):1880. doi: 10.1038/s41467-024-46090-5. Nat Commun. 2024. PMID: 38424098 Free PMC article.
Designed active-site library reveals thousands of functional GFP variants.
Weinstein JY, Martí-Gómez C, Lipsh-Sokolik R, Hoch SY, Liebermann D, Nevo R, Weissman H, Petrovich-Kopitman E, Margulies D, Ivankov D, McCandlish DM, Fleishman SJ. Weinstein JY, et al. Among authors: mccandlish dm. Nat Commun. 2023 May 20;14(1):2890. doi: 10.1038/s41467-023-38099-z. Nat Commun. 2023. PMID: 37210560 Free PMC article.
Cachexia: A systemic consequence of progressive, unresolved disease.
Ferrer M, Anthony TG, Ayres JS, Biffi G, Brown JC, Caan BJ, Cespedes Feliciano EM, Coll AP, Dunne RF, Goncalves MD, Grethlein J, Heymsfield SB, Hui S, Jamal-Hanjani M, Lam JM, Lewis DY, McCandlish D, Mustian KM, O'Rahilly S, Perrimon N, White EP, Janowitz T. Ferrer M, et al. Cell. 2023 Apr 27;186(9):1824-1845. doi: 10.1016/j.cell.2023.03.028. Cell. 2023. PMID: 37116469 Free PMC article. Review.
Robust genetic codes enhance protein evolvability.
Rozhoňová H, Martí-Gómez C, McCandlish DM, Payne JL. Rozhoňová H, et al. Among authors: mccandlish dm. PLoS Biol. 2024 May 16;22(5):e3002594. doi: 10.1371/journal.pbio.3002594. eCollection 2024 May. PLoS Biol. 2024. PMID: 38754362 Free PMC article.
Guidelines for releasing a variant effect predictor.
Livesey BJ, Badonyi M, Dias M, Frazer J, Kumar S, Lindorff-Larsen K, McCandlish DM, Orenbuch R, Shearer CA, Muffley L, Foreman J, Glazer AM, Lehner B, Marks DS, Roth FP, Rubin AF, Starita LM, Marsh JA. Livesey BJ, et al. Among authors: mccandlish dm. ArXiv [Preprint]. 2024 Apr 16:arXiv:2404.10807v1. ArXiv. 2024. PMID: 38699161 Free PMC article. Preprint.
Evolutionary paths that link orthogonal pairs of binding proteins.
Avizemer Z, Martí-Gómez C, Hoch SY, McCandlish DM, Fleishman SJ. Avizemer Z, et al. Among authors: mccandlish dm. Res Sq [Preprint]. 2023 Dec 13:rs.3.rs-2836905. doi: 10.21203/rs.3.rs-2836905/v1. Res Sq. 2023. PMID: 37131620 Free PMC article. Preprint.
39 results