Krainer AR - Search Results

1

Specificity, synergy, and mechanisms of splice-modifying drugs.

Ishigami Y, Wong MS, Martí-Gómez C, Ayaz A, Kooshkbaghi M, Hanson SM, McCandlish DM, Krainer AR, Kinney JB. Ishigami Y, et al. Among authors: krainer ar. Nat Commun. 2024 Feb 29;15(1):1880. doi: 10.1038/s41467-024-46090-5. Nat Commun. 2024. PMID: 38424098 Free PMC article.

2

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.

Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Nature. 2011 Oct 5;478(7367):123-6. doi: 10.1038/nature10485. Nature. 2011. PMID: 21979052 Free PMC article.

3

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.

Sivaramakrishnan M, McCarthy KD, Campagne S, Huber S, Meier S, Augustin A, Heckel T, Meistermann H, Hug MN, Birrer P, Moursy A, Khawaja S, Schmucki R, Berntenis N, Giroud N, Golling S, Tzouros M, Banfai B, Duran-Pacheco G, Lamerz J, Hsiu Liu Y, Luebbers T, Ratni H, Ebeling M, Cléry A, Paushkin S, Krainer AR, Allain FH, Metzger F. Sivaramakrishnan M, et al. Among authors: krainer ar. Nat Commun. 2017 Nov 14;8(1):1476. doi: 10.1038/s41467-017-01559-4. Nat Commun. 2017. PMID: 29133793 Free PMC article.

4

Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites.

Wong MS, Kinney JB, Krainer AR. Wong MS, et al. Among authors: krainer ar. Mol Cell. 2018 Sep 20;71(6):1012-1026.e3. doi: 10.1016/j.molcel.2018.07.033. Epub 2018 Aug 30. Mol Cell. 2018. PMID: 30174293 Free PMC article.

5

Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.

Ajiro M, Awaya T, Kim YJ, Iida K, Denawa M, Tanaka N, Kurosawa R, Matsushima S, Shibata S, Sakamoto T, Studer L, Krainer AR, Hagiwara M. Ajiro M, et al. Among authors: krainer ar. Nat Commun. 2021 Jul 23;12(1):4507. doi: 10.1038/s41467-021-24705-5. Nat Commun. 2021. PMID: 34301951 Free PMC article.

6

Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy.

Kim YJ, Nomakuchi T, Papaleonidopoulou F, Yang L, Zhang Q, Krainer AR. Kim YJ, et al. Among authors: krainer ar. Nat Commun. 2022 May 27;13(1):2978. doi: 10.1038/s41467-022-30668-y. Nat Commun. 2022. PMID: 35624092 Free PMC article.

7

Higher-order epistasis and phenotypic prediction.

Zhou J, Wong MS, Chen WC, Krainer AR, Kinney JB, McCandlish DM. Zhou J, et al. Among authors: krainer ar. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2204233119. doi: 10.1073/pnas.2204233119. Epub 2022 Sep 21. Proc Natl Acad Sci U S A. 2022. PMID: 36129941 Free PMC article.

8

Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer.

Wan L, Lin KT, Rahman MA, Ishigami Y, Wang Z, Jensen MA, Wilkinson JE, Park Y, Tuveson DA, Krainer AR. Wan L, et al. Among authors: krainer ar. Cancer Discov. 2023 Jul 7;13(7):1678-1695. doi: 10.1158/2159-8290.CD-22-1013. Cancer Discov. 2023. PMID: 37098965 Free PMC article.

9

Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing.

Horowitz DS, Krainer AR. Horowitz DS, et al. Among authors: krainer ar. Trends Genet. 1994 Mar;10(3):100-6. doi: 10.1016/0168-9525(94)90233-x. Trends Genet. 1994. PMID: 8178363 Review.

10

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.

Cartegni L, Krainer AR. Cartegni L, et al. Among authors: krainer ar. Nat Genet. 2002 Apr;30(4):377-84. doi: 10.1038/ng854. Epub 2002 Mar 4. Nat Genet. 2002. PMID: 11925564

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