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The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition.
Kalla C, Ott G, Finotello F, Niewola-Staszkowska K, Conza GD, Lahn M, van der Veen L, Schüler J, Falkenstern-Ge R, Kopecka J, Riganti C. Kalla C, et al. Among authors: lahn m. Transl Oncol. 2024 May;43:101857. doi: 10.1016/j.tranon.2023.101857. Epub 2024 Feb 27. Transl Oncol. 2024. PMID: 38412661 Free PMC article.
Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors.
Deken MA, Niewola-Staszkowska K, Peyruchaud O, Mikulčić N, Antolić M, Shah P, Cheasty A, Tagliavini A, Nizzardo A, Pergher M, Ziviani L, Milleri S, Pickering C, Lahn M, van der Veen L, Di Conza G, Johnson Z. Deken MA, et al. Among authors: lahn m. Immunooncol Technol. 2023 Apr 8;18:100384. doi: 10.1016/j.iotech.2023.100384. eCollection 2023 Jun. Immunooncol Technol. 2023. PMID: 37234285 Free PMC article.
Targeting T regulatory (Treg) cells in immunotherapy-resistant cancers.
Spiliopoulou P, Kaur P, Hammett T, Di Conza G, Lahn M. Spiliopoulou P, et al. Among authors: lahn m. Cancer Drug Resist. 2024 Jan 12;7:2. doi: 10.20517/cdr.2023.46. eCollection 2024. Cancer Drug Resist. 2024. PMID: 38318526 Free PMC article. Review.
Immunotherapy for brain metastases and primary brain tumors.
Di Giacomo AM, Mair MJ, Ceccarelli M, Anichini A, Ibrahim R, Weller M, Lahn M, Eggermont AMM, Fox B, Maio M. Di Giacomo AM, et al. Among authors: lahn m. Eur J Cancer. 2023 Jan;179:113-120. doi: 10.1016/j.ejca.2022.11.012. Epub 2022 Nov 24. Eur J Cancer. 2023. PMID: 36521332
Autotaxin Secretion Is a Stromal Mechanism of Adaptive Resistance to TGFβ Inhibition in Pancreatic Ductal Adenocarcinoma.
Pietrobono S, Sabbadini F, Bertolini M, Mangiameli D, De Vita V, Fazzini F, Lunardi G, Casalino S, Scarlato E, Merz V, Zecchetto C, Quinzii A, Di Conza G, Lahn M, Melisi D. Pietrobono S, et al. Among authors: lahn m. Cancer Res. 2024 Jan 2;84(1):118-132. doi: 10.1158/0008-5472.CAN-23-0104. Cancer Res. 2024. PMID: 37738399 Free PMC article. Clinical Trial.
141 results