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NCP, a dual kappa and mu opioid receptor agonist, is a potent analgesic against inflammatory pain without reinforcing or aversive properties.
Huang P, Ho CK, Cao D, Inan S, Rawls SM, Li M, Huang B, Pagare PP, Townsend EA, Poklis JL, Halquist MS, Banks M, Zhang Y, Liu-Chen LY. Huang P, et al. Among authors: huang b. J Pharmacol Exp Ther. 2024 Feb 26;389(1):106-17. doi: 10.1124/jpet.123.001870. Online ahead of print. J Pharmacol Exp Ther. 2024. PMID: 38409113 Free article.
Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation.
Wang Y, Li JG, Huang P, Xu W, Liu-Chen LY. Wang Y, et al. Among authors: huang p. J Pharmacol Exp Ther. 2003 Dec;307(3):1127-34. doi: 10.1124/jpet.103.055814. Epub 2003 Oct 13. J Pharmacol Exp Ther. 2003. PMID: 14557376
Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo.
Wang Y, Tang K, Inan S, Siebert D, Holzgrabe U, Lee DY, Huang P, Li JG, Cowan A, Liu-Chen LY. Wang Y, et al. Among authors: huang p. J Pharmacol Exp Ther. 2005 Jan;312(1):220-30. doi: 10.1124/jpet.104.073668. Epub 2004 Sep 21. J Pharmacol Exp Ther. 2005. PMID: 15383632
Localization of the kappa opioid receptor in lipid rafts.
Xu W, Yoon SI, Huang P, Wang Y, Chen C, Chong PL, Liu-Chen LY. Xu W, et al. Among authors: huang p. J Pharmacol Exp Ther. 2006 Jun;317(3):1295-306. doi: 10.1124/jpet.105.099507. Epub 2006 Feb 27. J Pharmacol Exp Ther. 2006. PMID: 16505160
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