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NCP, a dual kappa and mu opioid receptor agonist, is a potent analgesic against inflammatory pain without reinforcing or aversive properties.
Huang P, Ho CK, Cao D, Inan S, Rawls SM, Li M, Huang B, Pagare PP, Townsend EA, Poklis JL, Halquist MS, Banks M, Zhang Y, Liu-Chen LY. Huang P, et al. Among authors: cao d. J Pharmacol Exp Ther. 2024 Feb 26;389(1):106-17. doi: 10.1124/jpet.123.001870. Online ahead of print. J Pharmacol Exp Ther. 2024. PMID: 38409113 Free article.
Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects.
Cao D, Huang P, Chiu YT, Chen C, Wang H, Li M, Zheng Y, Ehlert FJ, Zhang Y, Liu-Chen LY. Cao D, et al. ACS Chem Neurosci. 2020 Oct 7;11(19):3036-3050. doi: 10.1021/acschemneuro.0c00407. Epub 2020 Sep 24. ACS Chem Neurosci. 2020. PMID: 32897695 Free PMC article.
Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors.
Huang B, Gunta R, Wang H, Li M, Cao D, Mendez RE, Gillespie JC, Chen C, Huang LM, Liu-Chen LY, Selley DE, Zhang Y. Huang B, et al. Among authors: cao d. Bioorg Chem. 2021 Apr;109:104702. doi: 10.1016/j.bioorg.2021.104702. Epub 2021 Feb 9. Bioorg Chem. 2021. PMID: 33631465 Free PMC article.
5,048 results