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Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.
Puumala E, Sychantha D, Lach E, Reeves S, Nabeela S, Fogal M, Nigam A, Johnson JW, Aspuru-Guzik A, Shapiro RS, Uppuluri P, Kalyaanamoorthy S, Magolan J, Whitesell L, Robbins N, Wright GD, Cowen LE. Puumala E, et al. Among authors: sychantha d. Cell Chem Biol. 2024 Apr 18;31(4):760-775.e17. doi: 10.1016/j.chembiol.2024.01.010. Epub 2024 Feb 22. Cell Chem Biol. 2024. PMID: 38402621 Free article.
Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa.
Marmont LS, Orta AK, Baileeves BWA, Sychantha D, Fernández-Galliano A, Li YE, Greene NG, Corey RA, Stansfeld PJ, Clemons WM Jr, Bernhardt TG. Marmont LS, et al. Among authors: sychantha d. Nat Microbiol. 2024 Mar;9(3):763-775. doi: 10.1038/s41564-024-01603-2. Epub 2024 Feb 9. Nat Microbiol. 2024. PMID: 38336881 Free PMC article.
Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp.
Ahmad S, Gordon IJ, Tsang KK, Alexei AG, Sychantha D, Colautti J, Trilesky SL, Kim Y, Wang B, Whitney JC. Ahmad S, et al. Among authors: sychantha d. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2213771120. doi: 10.1073/pnas.2213771120. Epub 2023 Mar 29. Proc Natl Acad Sci U S A. 2023. PMID: 36989297 Free PMC article.
23 results